{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:51:33Z","timestamp":1791589893480,"version":"4.3.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":836,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032517","name":"IDEXX Laboratories, Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032517","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine\u22121 or SDMA\u22121) has shown promise, but quantitative criteria to distinguish stable vs progressive CKD using this approach are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Assessment of creatinine\u22121 and SDMA\u22121 slope cutoffs to distinguish stable vs progressive CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred ten clinically healthy university staff-owned dogs and 29 male colony dogs with progressive X-linked hereditary nephropathy (XLHN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis combining 2 prospective observational studies, 1 tracking kidney function biomarkers in healthy dogs (HDs) to a maximum of 3\u2009years, and 1 tracking kidney function biomarkers in male colony dogs with progressive XLHN to a maximum of 1\u2009year. The minimum slope of creatinine\u22121 or SDMA\u22121 as measured using the IDEXX SDMA test from HD was assigned as the slope cutoff for stable kidney function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The stable vs progressive slope cutoff was \u22120.0119\u2009week\u2009\u00d7\u2009dL\/mg for creatinine\u22121 and \u22120.0007\u2009week\u2009\u00d7\u2009dL\/\u03bcg for SDMA\u22121.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>In the studied CKD population, progressive dysfunction can be distinguished from stable kidney function by using the slope of creatinine\u22121 or SDMA\u22121. These criteria may serve to characterize CKD in other cohorts of dogs and to establish guidelines for degrees of progression rate in dogs with naturally occurring CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16885","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:11:20Z","timestamp":1697793080000},"page":"2241-2250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differentiation of stable kidney function versus progressive dysfunction in dogs"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4780-2266","authenticated-orcid":false,"given":"Larry D.","family":"Cowgill","sequence":"first","affiliation":[{"name":"University of California-Davis , Davis, 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