{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:34:59Z","timestamp":1780461299497,"version":"3.54.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":836,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Institute of Health, National Cancer Institute","award":["1R43CA150703"],"award-info":[{"award-number":["1R43CA150703"]}]},{"name":"National Institute of Health, National Cancer Institute","award":["2R44CA150703"],"award-info":[{"award-number":["2R44CA150703"]}]},{"name":"National Institute of Health, National Cancer Institute","award":["R44CA210763-02"],"award-info":[{"award-number":["R44CA210763-02"]}]},{"name":"National Institute of Health, National Cancer Institute","award":["R44CA210763-03"],"award-info":[{"award-number":["R44CA210763-03"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The melanocortin 4 antagonist TCMCB07 is safe and effective in reversing cachexia caused by sepsis or cancer in rodents. The safety and pharmacokinetics of TCMCB07 are demonstrated in healthy beagle dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The objectives of this study were to investigate the safety, peak plasma concentrations, and potential for efficacy of TCMCB07 in pet dogs with naturally occurring cachexia over a 4-week time period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fourteen dogs with cachexia of any underlying cause, except cancer of the oral cavity or gastrointestinal tract, were eligible for enrollment with informed client consent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a prospective, 1-armed open-label trial. Physical examination, complete blood count, chemistry panel, and owner-assessed quality of life surveys were checked at weeks 1, 2, and 4. Due to potential for bradycardia and hypotension, Holter monitoring and blood pressure evaluations were scheduled at pre-enrollment and week 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen dogs completed the trial. Significant changes detected included increased mean body weight (18.6-19.5\u2009kg, P\u2009&amp;lt;\u2009.02), increased body condition score (median Tufts 5-point thin dog scale score P\u2009&amp;lt;\u2009.004 and WSAVA muscle condition score P\u2009&amp;lt;\u2009.02) and increased mean blood urea nitrogen (21.79-30.43\u2009mg dL\u22121, P\u2009&amp;lt;\u2009.004). On quality of life surveys, pet owners perceived their dog appeared to be panting less (P\u2009&amp;lt;\u2009.002) and that the general health improved (P\u2009&amp;lt;\u2009.03). Four dogs had a change in coat pigmentation. The peak plasma concentration of TCMCB07 in cachectic dogs was similar to that in healthy beagle dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>TCMCB07 was safe and has potential efficacy in pet dogs with cachexia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16915","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T07:28:51Z","timestamp":1698478131000},"page":"2344-2355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety of TCMCB07, a melanocortin-4 antagonist peptide, in dogs with naturally occurring cachexia"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-5959","authenticated-orcid":false,"given":"Sandra M.","family":"Axiak-Bechtel","sequence":"first","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7538-9071","authenticated-orcid":false,"given":"Stacey B.","family":"Leach","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Newton-Northup","sequence":"additional","affiliation":[{"name":"TCI Peptide Therapeutics , Columbia, Missouri,","place":["USA"]},{"name":"Cell Origins LLC , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-2058","authenticated-orcid":false,"given":"Rowan J.","family":"Milner","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Fox-Alvarez","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana I.","family":"Fagman","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee A.","family":"Young","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Tate","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Wright","sequence":"additional","affiliation":[{"name":"VCA Animal Diagnostic Clinic , Dallas, Texas,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Chretin","sequence":"additional","affiliation":[{"name":"VCA West Los Angeles , Los Angeles, California,","place":["USA"]},{"name":"VCA Veterinary Specialists of the Valley , Woodland Hills, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-0542","authenticated-orcid":false,"given":"Justin W.","family":"Allen","sequence":"additional","affiliation":[{"name":"VCA West Los Angeles , Los Angeles, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean K.","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"VCA West Los Angeles , Los Angeles, California,","place":["USA"]},{"name":"VCA Animal Specialty and Emergency Center , Los Angeles, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Selting","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, Missouri,","place":["USA"]},{"name":"College of Veterinary Medicine, University of Illinois Urbana-Champaign Department of Veterinary Clinical Medicine, , Urbana, Illinois,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Flesner","sequence":"additional","affiliation":[{"name":"University of Missouri Department of Veterinary Medicine and Surgery, , Columbia, Missouri,","place":["USA"]},{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Sciences and Advanced Medicine, , Philadelphia, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie R.","family":"White","sequence":"additional","affiliation":[{"name":"VCA Family and Oahu Veterinary Specialty Center , Pearl City, Hawaii,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Mills","sequence":"additional","affiliation":[{"name":"VCA Clinical Studies , Los Angeles, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-9256","authenticated-orcid":false,"given":"Michael","family":"Aherne","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Bergman","sequence":"additional","affiliation":[{"name":"VCA Clinical Studies , Los Angeles, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeAnn","family":"Qi","sequence":"additional","affiliation":[{"name":"TCI Peptide Therapeutics , Columbia, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Gruber","sequence":"additional","affiliation":[{"name":"TCI Peptide Therapeutics , Columbia, Missouri,","place":["USA"]},{"name":"University of Missouri 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