{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:17:03Z","timestamp":1773850623231,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":764,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Open access funding provided by the Iowa State University Library."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Predicting progression of myxomatous mitral valve disease (MMVD) in dogs can be challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The mitral regurgitation severity index (MRSI) will predict time to congestive heart failure (CHF) and all-cause death in dogs with MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eight hundred sixty-nine client-owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study pooling data from 4 previous samples including dogs with MMVD stage B2 or C. MRSI was calculated as: (heart rate [HR]\/120)\u2009\u00d7\u2009left atrium-to-aorta ratio (LA:Ao)\u2009\u00d7\u2009(age in years\/10)\u2009\u00d7\u2009100. Alternative MRSI formulas substituting radiographic measures of left atrial size were also calculated. Cox proportional hazard modeling and time-dependent receiver-operator characteristic curves quantified prognostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For Stage B2 pooled samples, MRSI\u2009&amp;gt;\u2009156 was predictive of time to CHF (median 407 vs 1404\u2009days; area under the curve [AUC] 0.68; hazard ratio 3.02 [95% CI 1.9-4.9]; P\u2009&amp;lt;\u2009.001). MRSI\u2009&amp;gt;\u2009173 was predictive of all-cause death (median survival 868 vs 1843\u2009days; AUC 0.64; hazard ratio 4.26 [95% CI 2.4-7.5]; P\u2009&amp;lt;\u2009.001). MRSI showed superior predictive value compared to the individual variables of HR, LA:Ao, and age. Variations of the MRSI equation substituting radiographic vertebral left atrial size for LA:Ao were also significantly predictive of outcome in stage B2. MRSI was not consistently predictive of outcome in Stage C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>MRSI was predictive of outcome (onset of CHF and all-cause death) in MMVD Stage B2, demonstrating utility as a useful prognostic tool. Echocardiographic LA:Ao can be effectively replaced by radiographically determined LA size in the MRSI formula.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16923","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:40:00Z","timestamp":1698824400000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of a mitral regurgitation severity index to predict long-term outcome in dogs with myxomatous mitral valve disease"],"prefix":"10.1093","volume":"38","author":[{"given":"Michelle","family":"Vereb","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University Department of Veterinary Clinical Sciences, , Ames, Iowa,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4463-4625","authenticated-orcid":false,"given":"Clarke 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