{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:21:05Z","timestamp":1781288465391,"version":"3.54.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":764,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pituitary-dependent hypersomatotropism is rarely diagnosed in dogs and surgical treatment is not reported. A 6-year-10-month male neutered Patterdale Terrier presented with polyuria, polydipsia, progressive pharyngeal stertor, excessive hair growth and widened facial features and paws. Serum insulin-like growth factor-1 concentration via radioimmunoassay was consistent with hypersomatotropism (1783\u2009ng\/mL). A pituitary mass was identified on magnetic resonance and computed tomography imaging. Six weeks later, glucosuria, starved hyperglycemia and serum fructosamine above the reference range (467.6 \u03bcmol\/L, RI 177-314) were documented, consistent with diabetes mellitus. Transsphenoidal hypophysectomy was performed under general anesthesia without complications. Pituitary histopathology identified an acidophil neoplasm, with positive immunostaining for growth hormone. Postoperatively, there was rapid resolution of clinical, biochemical and morphologic changes of hypersomatotropism with persistence of diabetes mellitus. This case demonstrates successful resolution of hypersomatotropism with ongoing diabetes mellitus in a dog after surgical treatment by transsphenoidal hypophysectomy.<\/jats:p>","DOI":"10.1111\/jvim.16929","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:20:01Z","timestamp":1698909601000},"page":"351-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transsphenoidal hypophysectomy for the treatment of hypersomatotropism secondary to a pituitary somatotroph adenoma in a dog"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1395-6506","authenticated-orcid":false,"given":"Matthew M. E.","family":"Steele","sequence":"first","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack S.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Scudder","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice H.","family":"Watson","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola T. Z.","family":"Ho","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and Services, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-0672","authenticated-orcid":false,"given":"Dylan","family":"Yaffy","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Pathobiology and Population Sciences, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Batchelor","sequence":"additional","affiliation":[{"name":"University of Liverpool Department of Small Animal Clinical Sciences, , Neston,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-670X","authenticated-orcid":false,"given":"Joe","family":"Fenn","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Clinical Science and 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