{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:19:35Z","timestamp":1789690775779,"version":"4.0.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":764,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-148807"],"award-info":[{"award-number":["PJT-148807"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010148807"],"award-info":[{"award-number":["PJT\u2010148807"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Altered innervation structure and function contribute to airway hyperresponsiveness in human asthma, yet the role of innervation in airflow limitation in asthma in horses remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>To characterize peribronchial innervation in horses with asthma. We hypothesized that airway innervation increases in horses with asthma compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Formalin-fixed lung samples from 8 horses with severe asthma and 8 healthy horses from the Equine Respiratory Tissue Biobank. Ante-mortem lung function was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blinded case-control study. Immunohistochemistry was performed using rabbit anti-s100 antibody as a neuronal marker for myelinating and non-myelinating Schwann cells. The number and cumulative area of nerves in the peribronchial region and associated with airway smooth muscle were recorded using histomorphometry and corrected for airway size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both the number (median [IQR]: 1.87\u2009\u00d7\u200910\u22125 nerves\/\u03bcm2 [1.28\u2009\u00d7\u200910\u22125]) and the cumulative nerve area (CNA; 1.03\u2009\u00d7\u200910\u22123 CNA\/\u03bcm2 [1.57\u2009\u00d7\u200910\u22123]) were higher in the peribronchial region of horses with asthma compared with controls (5.17\u2009\u00d7\u200910\u22126 nerves\/\u03bcm2 [3.76\u2009\u00d7\u200910\u22126], 4.14\u2009\u00d7\u200910\u22124 CNA\/\u03bcm2 [2.54\u2009\u00d7\u200910\u22124], Mann-Whitney, P\u2009=\u2009.01). The number of nerves within or lining airway smooth muscle was significantly higher in horses with asthma (4.47\u2009\u00d7\u200910\u22126 nerves\/\u03bcm2 [5.75\u2009\u00d7\u200910\u22126]) compared with controls (2.26\u2009\u00d7\u200910\u22126 nerves\/\u03bcm2 [1.16\u2009\u00d7\u200910\u22126], Mann-Whitney, P\u2009=\u2009.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Asthma in horses is associated with greater airway innervation, possibly contributing to airway smooth muscle remodeling and exacerbating severity of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16941","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T03:59:41Z","timestamp":1701835181000},"page":"485-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severe asthma in horses is associated with increased airway innervation"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6676-7137","authenticated-orcid":false,"given":"Laurence","family":"Leduc","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al Department of Clinical Sciences, , Saint-Hyacinthe, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-0370","authenticated-orcid":false,"given":"Mathilde","family":"Lecl\u00e8re","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al Department of Clinical Sciences, , Saint-Hyacinthe, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie Girardot","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge Andr\u00e9 Grasset , Montr\u00e9al, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Marcil","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge Andr\u00e9 Grasset , Montr\u00e9al, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-2102","authenticated-orcid":false,"given":"Jean-Pierre","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al Department of Clinical Sciences, , Saint-Hyacinthe, Quebec,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"issue":"1","key":"2026020304052187800_jvim16941-bib-0001","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2746\/042516407X180129","article-title":"A survey of horse owners in Great Britain regarding horses in their care. 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