{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:19:21Z","timestamp":1783955961338,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":764,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Feline infectious peritonitis (FIP) historically has been a fatal disease in cats. Recent unlicensed use of antiviral medication has been shown to markedly improve survival of this infection. An 8-month-old female spayed domestic short-haired cat undergoing treatment for presumptive FIP with the antiviral nucleoside analog GS-441524 developed acute progressive azotemia. Abdominal ultrasound examination identified multifocal urolithiasis including renal, ureteral, and cystic calculi. Unilateral ureteral obstruction progressed to suspected bilateral ureteral obstruction and subcutaneous ureteral bypass (SUB) was performed along with urolith removal and submission for analysis. A 2-year-old male neutered domestic medium-haired cat undergoing treatment for confirmed FIP with GS-441524 developed dysuria (weak urine stream, urinary incontinence, and difficulty expressing the urinary bladder). This cat also was diagnosed sonographically with multifocal urolithiasis requiring temporary tube cystostomy after cystotomy and urolith removal. In both cases, initial urolith analysis showed unidentified material. Additional testing confirmed the calculi in both cats to be 98% consistent with GS-441524. Additional clinical studies are required to determine best screening practices for cats presented for urolithiasis during treatment with GS-441524.<\/jats:p>","DOI":"10.1111\/jvim.16954","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:29:20Z","timestamp":1701329360000},"page":"370-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Uroliths composed of antiviral compound GS-441524 in 2 cats undergoing treatment for feline infectious peritonitis"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2715-5762","authenticated-orcid":false,"given":"Marissa","family":"Allinder","sequence":"first","affiliation":[{"name":"Clinical Veterinary Pharmacy, Charleston Veterinary Referral Center , Charleston, South Carolina,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Tynan","sequence":"additional","affiliation":[{"name":"Critical Care, Charleston Veterinary Referral Center , Charleston, South Carolina,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Martin","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia , Athens, Georgia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Furbish","sequence":"additional","affiliation":[{"name":"Dept. of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina , Charleston, South Carolina,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Austin","sequence":"additional","affiliation":[{"name":"Louis C. Herring & Company , Orlando, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Bartges","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia , Athens, Georgia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-4645","authenticated-orcid":false,"given":"Bianca N.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia , Athens, Georgia,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"2026020304053928200_jvim16954-bib-0001","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jfms.2008.09.008","article-title":"A review of feline infectious peritonitis virus infection: 1963-2008","volume":"11","author":"Pedersen","year":"2009","journal-title":"J Feline Med Surg"},{"key":"2026020304053928200_jvim16954-bib-0002","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1098612X19825701","article-title":"Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis","volume":"21","author":"Pedersen","year":"2019","journal-title":"J Feline Med Surg"},{"issue":"1","key":"2026020304053928200_jvim16954-bib-0003","article-title":"Curing cats with feline infectious peritonitis with an oral multi-component drug containing GS-441524","volume":"13","author":"Krentz","year":"2021","journal-title":"Viruses"},{"issue":"1","key":"2026020304053928200_jvim16954-bib-0004","article-title":"Unlicensed GS-441524-like antiviral therapy can be effective for at-home treatment of feline infectious peritonitis","volume":"11","author":"Jones","year":"2021","journal-title":"Animals"},{"issue":"1","key":"2026020304053928200_jvim16954-bib-0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cvsm.2008.09.011","article-title":"Analysis of 451,891 canine uroliths, feline uroliths, and feline urethral plugs from 1981 to 2007: perspectives from the Minnesota Urolith Center","volume":"39","author":"Osborne","year":"2009","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020304053928200_jvim16954-bib-0006","article-title":"Urolith Analysis Overview. 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