{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:14:05Z","timestamp":1783952045809,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":764,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The utility of neutrophil-to-lymphocyte ratio (NLR), platelet to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) as prognostic indicators has not been investigated in canine parvovirosis (CPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>To evaluate whether these hematological ratios obtained at hospital admission in CPV are associated with outcome or duration of hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Four hundred one client-owned dogs presented with CPV. Methods-Retrospective multicenter cohort study. Medical records were reviewed to identify dogs with CPV. Data regarding signalment, complete blood count at admission, duration of hospitalization and outcome were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 401 dogs included in the study, 336 (83.8%) survived to discharge. The median (25th and 75th percentiles) PLR in nonsurvivors (336.56 [159.84-635.77]) was significantly higher than in survivors (217.65 [117.67-389.65]) (P\u2009=\u2009.003). The area under the receiver-operating characteristic curve for nonsurvival was 0.615 (95% CI [0.593-0.691], P\u2009=\u2009.003). A cut off of 700 showed a 21.5% sensitivity and 90% specificity for nonsurvival. No association was observed between hospitalization duration and either hematological ratios or total WBC counts. The median (25th and 75th percentiles) lymphocyte count was below reference interval in all dogs and was significantly lower in the dogs which died (0.82 \u00d7\u2009109\/L [0.5-1.87]) than in survivors (1.27 \u00d7\u2009109\/L [0.73-2.22]) (P\u2009=\u2009.005). The median (25th and 75th percentiles) monocyte count however was lower in survivors (0.38 \u00d7\u2009109\/L [0.29-1.59]), than in nonsurvivors (0.73 \u00d7\u2009109\/L [0.1-2]) (P\u2009=\u2009.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evaluation of PLR at hospital admission might be a useful marker of disease severity and\u00a0could have prognostic value in dogs with CPV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16972","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T13:56:34Z","timestamp":1702648594000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Retrospective evaluation of hematological ratios in canine parvovirosis: 401 cases"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9304-4552","authenticated-orcid":false,"given":"Andrea","family":"Gonz\u00e1lez-Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Veterinary Teaching Hospital of the Catholic University of Valencia\u2014Emergency and critical care , Valencia,","place":["Spain"]},{"name":"Universidad de Leon\u2014Veterinary Teaching Hospital, Emergency and Critical Care , Leon, Castilla y Le\u00f3n,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-7690","authenticated-orcid":false,"given":"Jos\u00e9 Ignacio","family":"Cristobal-Verdejo","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura\u2014Medicine Care , Badajoz, Extremadura,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"L\u00f3pez-Espinar","sequence":"additional","affiliation":[{"name":"Universidad de Extremadura\u2014Animal Medicine , Badajoz,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Fontela-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Veterinary Hospital Auna Especialidades\u2014Emergency and Critical Care , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-5747","authenticated-orcid":false,"given":"Sergio","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Servicio de Oncolog\u00eda, IVC Evidensia A\u00fana Especialidades Veterinarias , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Justo-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Veterinary Hospital Puchol , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan","family":"Gonz\u00e1lez-Caramazana","sequence":"additional","affiliation":[{"name":"AniCura Valencia Sur Veterinary Hospital\u2014Section of Neurology and Neurosurgery , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Bragado-Cuesta","sequence":"additional","affiliation":[{"name":"AniCura Valencia Sur Veterinary Hospital\u2014Emergency and Critical Care , Valencia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"\u00c1lvarez-Punzano","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital of the Alfonso X El Sabio\u2014Emergency and Critical Care , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente J.","family":"Herrer\u00eda-Bustillo","sequence":"additional","affiliation":[{"name":"Veterinary 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