{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:08:34Z","timestamp":1770156514173,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":704,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n No treatment other than platelet administration is known to protect against spontaneous hemorrhage in thrombocytopenic dogs.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n Primary: determine if treatment with \u03b5-aminocaproic acid (EACA) decreases the requirement for blood transfusions and improves outcome in dogs with severe thrombocytopenia. Secondary: find evidence of hyperfibrinolysis and determine the effect EACA administration on rapid (rTEG) and tissue plasminogen activator-spiked (tPA-rTEG) thromboelastography parameters.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Twenty-seven dogs with severe thrombocytopenia were treated with EACA, and data from an additional 33 were obtained from the hospital database as historical control (HC) cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Single arm clinical trial with HCs. The EACA group dogs received EACA (100\u2009mg\/kg IV followed by a constant-rate infusion [CRI] of 400\u2009mg\/kg\/24\u2009hours). Thromboelastography before and during EACA infusion, hospitalization days, number of transfusions, and mortality were compared.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n No difference was found in number of transfusions per dog (median, interquartile range; 1, 0-2.5 vs 0.9, 0-2; P\u2009=\u2009.5) and hospitalization days (4, 4-6 vs 4.5, 3.75-6; P\u2009=\u2009.83) between HC and EACA groups, respectively, and no difference in survival was identified by log-rank analysis (P\u2009=\u2009.15). Maximum amplitude on both rTEG and tPA-rTEG increased after EACA administration (rTEG baseline: 23.6, 9.6-38.9; post-EACA: 27.3, 19.8-43.2; P\u2009&lt;\u2009.001; tPA-rTEG baseline: 23, 10.9-37.2; post-EACA: 24.7, 16.7-44.8; P\u2009&lt;\u2009.002).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n Although EACA increased clot strength, there was no effect on outcome. Treatment with EACA at this dosage cannot be recommended as a routine treatment but may be considered for dogs with severe ongoing hemorrhage.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.16977","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T13:23:13Z","timestamp":1704979393000},"page":"1013-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of \u03b5-aminocaproic acid on blood product requirement, outcome and thromboelastography parameters in severely thrombocytopenic dogs"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-1845","authenticated-orcid":false,"given":"Johanna","family":"Wolf","sequence":"first","affiliation":[{"name":"Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus , Midlothian,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura 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