{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:09:31Z","timestamp":1788419371710,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":704,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intervertebral disc herniation (IVDH) is the most common spinal cord disease in dogs. Little information is available regarding the clinical presentation of nerve root signature (NRS) associated with cervical IVDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objective<\/jats:title>\n                    <jats:p>To detail the clinical and magnetic resonance imaging (MRI) findings in dogs with NRS associated with cervical IVDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-seven client-owned dogs presenting with thoracic limb NRS and MRI confirmed IVDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records from 2010 to 2020 were retrospectively reviewed for dogs that met inclusion criteria. Imaging studies were evaluated by 2 individuals to characterize location and severity of neural tissue compression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chondrodystrophoid dogs comprised the majority of the study cohort, with dachshund the most common breed (n\u2009=\u200910). Three-quarters of dogs were \u22657\u2009years of age. Interobserver agreement was moderate or good for all of the imaging variables evaluated. The C6-C7 intervertebral disc space was significantly overrepresented (P\u2009=\u2009.01), comprising 32% (15\/47) of the affected discs. However, 42% (20\/47) of cases involved C2-C3 though C4-C5 disc sites. Disc material was more frequently located laterally compared to medially within the vertebral canal (P\u2009=\u2009.0005), and to be associated with compression of the nerve root at the level of the intervertebral foramen (P\u2009=\u2009.012).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\/Clinical Importance<\/jats:title>\n                    <jats:p>NRS is most commonly associated with lateralized or foraminal cervical disc herniations. It is most prevalent with C6-C7 intervertebral disc involvement, suggesting that there might be unique anatomic factors that contribute to development of NRS at this site, but can be a clinical manifestation of IVDH occurring anywhere along the cervical spine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16982","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T22:39:12Z","timestamp":1705099152000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and imaging findings in dogs with nerve root signature associated with cervical intervertebral disc herniation"],"prefix":"10.1093","volume":"38","author":[{"given":"Jordan","family":"Schachar","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Clinical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]},{"name":"Garden State Veterinary Specialists , Tinton, New Jersey,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bocage","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Molecular and Biomedical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]},{"name":"Mount Laurel Animal Hospital , Mount Laurel, New Jersey,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3765-1694","authenticated-orcid":false,"given":"Nathan C.","family":"Nelson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Molecular and Biomedical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-8500","authenticated-orcid":false,"given":"Peter J.","family":"Early","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Clinical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-6536","authenticated-orcid":false,"given":"Christopher L.","family":"Mariani","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Clinical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-3484","authenticated-orcid":false,"given":"Natasha J.","family":"Olby","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Clinical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9592-6276","authenticated-orcid":false,"given":"Karen R.","family":"Mu\u00f1ana","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, NC State University Department of Clinical Sciences, , Raleigh, North Carolina 27606,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"2026020304065413900_jvim16982-bib-0001","first-page":"135","article-title":"Incidence of clinical disc disease in the dog","volume":"11","author":"Gage","year":"1975","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020304065413900_jvim16982-bib-0002","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.2460\/ajvr.1970.31.09.1687","article-title":"Canine intervertebral disk disease: characterization by age, sex, breed, and anatomic site of involvement","volume":"31","author":"Goggin","year":"1970","journal-title":"Am J Vet Res"},{"key":"2026020304065413900_jvim16982-bib-0003","first-page":"165","article-title":"Surgical treatment of cervical disc herniations in ambulatory dogs. 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