{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:59:58Z","timestamp":1792814398914,"version":"4.5.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":704,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02536-MOU"],"award-info":[{"award-number":["02536-MOU"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02536\u2010MOU"],"award-info":[{"award-number":["02536\u2010MOU"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Identify clinicopathologic features that differentiate pITP from secondary ITP (sITP) and markers related to bleeding severity, transfusion, and survival of dogs with pITP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ninety-eight thrombocytopenic dogs (58 pITP and 40 sITP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Client-owned dogs with platelet counts &amp;lt;50\u2009000\/\u03bcL were enrolled in a prospective, multi-institution cohort study. History and treatment information, through a maximum of 7\u2009days, was recorded on standard data forms. Bleeding severity was scored daily using a bleeding assessment tool (DOGiBAT). At-admission blood samples were collected for CBC, biochemistry, C-reactive protein concentration, and coagulation panels, and to measure platelet surface-associated immunoglobulin G (PSAIg) and expression of platelet membrane proteins and phospholipids. Dogs with evidence of coincident disease were classified as sITP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No definitive pITP diagnostic test was found. However, pITP cases were characterized by lower platelet counts, D dimer concentrations, and platelet membrane protein expression than sITP cases. Differentiation between pITP and sITP was further enhanced using logistic regression modeling combining patient sex, coagulation profile, platelet count, D dimer, and PSAIg. A second model of pITP severity indicated that low hematocrit and high BUN concentration were associated with non-survival. Low hematocrit at admission, but not platelet count or DOGiBAT score, was associated with transfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Pending validation studies, models constructed from at-admission clinicopathologic findings may improve differentiation of pITP from sITP and identify the most severe pITP cases at the time of presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.16985","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:44:20Z","timestamp":1704951860000},"page":"1022-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-9013","authenticated-orcid":false,"given":"Marjory B.","family":"Brooks","sequence":"first","affiliation":[{"name":"Population Medicine & Diagnostic Sciences, Cornell University, 240 Farrier Road , Ithaca, New York 14853,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7446-6987","authenticated-orcid":false,"given":"Robert","family":"Goggs","sequence":"additional","affiliation":[{"name":"Clinical Sciences, C3-502D Clinical Programs Center, Cornell University, 930 Campus Road , Ithaca, New York 14853-0001,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia H.","family":"Frye","sequence":"additional","affiliation":[{"name":"Population Medicine & Diagnostic Sciences, Cornell University, 240 Farrier Road , Ithaca, New York 14853,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Armato","sequence":"additional","affiliation":[{"name":"Internal Medicine, Cornell University Veterinary Specialists , Stamford, Connecticut,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnin","family":"Forman","sequence":"additional","affiliation":[{"name":"Internal Medicine, Cornell University Veterinary Specialists , Stamford, Connecticut,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hertl","sequence":"additional","affiliation":[{"name":"Population Medicine & Diagnostic Sciences, Cornell University, 240 Farrier Road , Ithaca, New York 14853,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Koch","sequence":"additional","affiliation":[{"name":"Veterinary Internal Medicine Consulting , Rochester, New 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