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Treatment of insulin and dietary management was initiated. The insulin dose was gradually reduced and eventually discontinued over the next year based on spot blood glucose concentrations that revealed euglycemia or hypoglycemia. After discontinuation, the dog remained free of clinical signs for 1\u2009year until it was again presented for polyuria\/polydipsia with fasting hyperglycemia and glucosuria. Insulin therapy was resumed and continued for the remainder of the dog's life. Although diabetic remission often occurs in cats and humans, the presumed etiopathogenesis of pancreatic beta cell loss makes remission rare in dogs, except for cases occurring with diestrus or pregnancy. This case demonstrates that diabetic remission is possible in dogs, even in cases without an identifiable reversible trigger.<\/jats:p>","DOI":"10.1111\/jvim.16991","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T05:09:16Z","timestamp":1705640956000},"page":"1152-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Spontaneous remission and relapse of diabetes mellitus in a male dog"],"prefix":"10.1093","volume":"38","author":[{"given":"Mariola B.","family":"Rak","sequence":"first","affiliation":[{"name":"University of Tennessee Department of Small Animal Clinical Sciences at the College of Veterinary Medicine, , Knoxville, Tennessee,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-4135","authenticated-orcid":false,"given":"Chen","family":"Gilor","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9667-6678","authenticated-orcid":false,"given":"Stijn J. 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