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Whole blood was collected from each donor using transfusion bags with a LR filter. Leukoreduction pRBC and nLR-pRBC units were obtained and stored at 4\u00b0C for up 42\u2009days. Sterile weekly sampling was performed from each unit for analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Red blood cells and supernatants progressively accumulated lactate products while high-energy phosphate compounds (adenosine triphosphate and 2,3-Diphosphoglycerate) declined. Hypoxanthine, xanthine, and free fatty acids accumulated in stored RBC and supernatants. These lesions were exacerbated in non-LR-pRBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Leukoreduction has a beneficial effect on RBC energy and redox metabolism of equine pRBC and the onset and severity of the metabolic storage lesions RBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17015","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T05:35:46Z","timestamp":1708925746000},"page":"1185-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of leukoreduction on the metabolism of equine packed red blood cells during refrigerated storage"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5459-6298","authenticated-orcid":false,"given":"Arianna","family":"Miglio","sequence":"first","affiliation":[{"name":"University of Perugia Department of Veterinary Medicine, , Perugia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rocconi","sequence":"additional","affiliation":[{"name":"Veterinary University Hospital, University of Teramo Department of Veterinary Medicine, , Teramo,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cremonini","sequence":"additional","affiliation":[{"name":"University of Perugia Department of Veterinary Medicine, , Perugia,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6490","authenticated-orcid":false,"given":"Angelo","family":"D'Alessandro","sequence":"additional","affiliation":[{"name":"University of Colorado Denver\u2014Anschutz Medical Campus Department of Biochemistry and Molecular Genetics, , Aurora, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Reisz","sequence":"additional","affiliation":[{"name":"University of Colorado Denver\u2014Anschutz Medical Campus Department of Biochemistry and Molecular Genetics, , Aurora, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Maslanka","sequence":"additional","affiliation":[{"name":"University of Colorado Denver\u2014Anschutz Medical Campus Department of Biochemistry and Molecular Genetics, , Aurora, 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