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A litter of 4 dogs living in a T cruzi endemic area were randomized to prophylaxis and nonprophylaxis groups as part of a study evaluating a modified benznidazole dosing regimen administered twice weekly to prevent T cruzi infection during a vector transmission season. The 2 dogs that received prophylaxis remained healthy without T cruzi infection or cardiac disease for &amp;gt;2\u2009years. One dog that did not receive prophylaxis died unexpectedly with acute T cruzi\u2013induced pancarditis, and the second dog tested positive for T cruzi and developed complex arrhythmias with markedly increased cardiac troponin I and improved with a higher benznidazole treatment dose. Although the small sample size precludes definitive conclusions, we describe the potential clinical benefit of prophylactic and early treatment with modified benznidazole dosing regimens for dogs with T cruzi infection.<\/jats:p>","DOI":"10.1111\/jvim.17028","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:36:55Z","timestamp":1710819415000},"page":"1725-1729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Positive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with\n                    <i>Trypanosoma cruzi<\/i>"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1817-0089","authenticated-orcid":false,"given":"Sukjung","family":"Lim","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Department of Small Animal Clinical Sciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Collins","sequence":"additional","affiliation":[{"name":"Jourdanton, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Hamer","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Research, Texas A&M University Department of Veterinary Integrative Biosciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick L.","family":"Tarleton","sequence":"additional","affiliation":[{"name":"University of Georgia Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, , Athens, Georgia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-3894","authenticated-orcid":false,"given":"Ashley 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