{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:51:28Z","timestamp":1770159088189,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":643,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Linnaeus Veterinary Limited"},{"name":"Linnaeus Veterinary supported the cost of the open access publication charges"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 7-month-old male French bulldog was referred for abnormal mentation and gait. Physical examination revealed a dome shaped calvarium and persistent bregmatic fontanelle. Neurological examination revealed proprioceptive ataxia, pelvic limb paraparesis and strabismus with moderate ventriculomegaly, thinning of the cerebral parenchyma, and widened cerebral sulci on magnetic resonance imaging. Masses were identified in the region of the thyroid, which appeared heterogeneous and hyperintense in T1-weighted and T2-weighted compared with the adjacent muscle signal masses were identified. Radiological diagnosis was hydrocephalus \u201cex vacuo\u201d and goiter. Blood test revealed abnormally low total thyroxine (TT4), free thyroxine (FT4), and normal thyrotropin concentration. A diagnosis of congenital hypothyroidism was confirmed by positive genetic test for thyroid peroxidase mutation. Thyroxine supplementation treatment rapidly improved clinical signs.<\/jats:p>","DOI":"10.1111\/jvim.17029","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:41:10Z","timestamp":1711500070000},"page":"1737-1743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and magnetic resonance imaging findings in a French bulldog puppy with genetically confirmed congenital hypothyroidism"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7049-9827","authenticated-orcid":false,"given":"Katia S\u00e1nchez","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Northwest Veterinary Specialists , Runcorn,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Warwick","sequence":"additional","affiliation":[{"name":"Northwest Veterinary Specialists , Runcorn,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Conradie","sequence":"additional","affiliation":[{"name":"Northwest Veterinary Specialists , Runcorn,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1820-4717","authenticated-orcid":false,"given":"Neringa","family":"Alisauskaite","sequence":"additional","affiliation":[{"name":"Northwest Veterinary Specialists , Runcorn,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"issue":"3","key":"2026020305110222600_jvim17029-bib-0001","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/00480169.2011.567964","article-title":"Congenital hypothyroidism of dogs and cats: a review","volume":"59","author":"Bojanic","year":"2011","journal-title":"N Z Vet J"},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0002","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1111\/j.1939-1676.2012.01015.x","article-title":"Congenital hypothyroidism with goiter in Tenterfield terriers","volume":"26","author":"Dodgson","year":"2012","journal-title":"J Vet Intern Med"},{"key":"2026020305110222600_jvim17029-bib-0003","first-page":"4029","article-title":"The Metabolic & Molecular Bases of Inherited Disease","author":"Refetoff","year":"2001","edition":"8th ed."},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0004","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1939-1676.2003.tb01323.x","article-title":"Congenital hypothyroidism with goiter in Toy Fox Terriers","volume":"17","author":"Fyfe","year":"2003","journal-title":"J Vet Intern Med"},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1354\/vp.44-1-50","article-title":"CNS hypomyelination in rat terrier dogs with congenital goiter and a mutation in the thyroid peroxidase gene","volume":"44","author":"Pettigrew","year":"2007","journal-title":"Vet Pathol"},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0006","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00335-012-9442-y","article-title":"A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure","volume":"24","author":"Fyfe","year":"2013","journal-title":"Mamm Genome"},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0007","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/jvim.13651","article-title":"Molecular genetic characterization of thyroid dyshormonogenesis in a French bulldog","volume":"29","author":"Major","year":"2015","journal-title":"J Vet Intern Med"},{"key":"2026020305110222600_jvim17029-bib-0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.domaniend.2018.04.005","article-title":"Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium\/iodide symporter (SLC5A5) mutation in a family of Shih-tzu dogs","volume":"65","author":"Soler Arias","year":"2018","journal-title":"Domest Anim Endocrinol"},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0009","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/thy.1994.4.107","article-title":"The disorders induced by iodine deficiency","volume":"4","author":"Delange","year":"1994","journal-title":"Thyroid"},{"issue":"3","key":"2026020305110222600_jvim17029-bib-0010","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/01652176.2001.9695117","article-title":"Commercial diet induced hypothyroidism due to high iodine. 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