{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:09:00Z","timestamp":1774616940243,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":643,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hebrew University Veterinary Teaching Hospital Clinical Studies Fund","award":["20884"],"award-info":[{"award-number":["20884"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thromboelastometry (TEM) provides a comprehensive overview of the entire coagulation process and has not been evaluated in heatstroke-induced coagulopathies in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the diagnostic and prognostic utility of TEM in dogs with heatstroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-two client-owned dogs with heatstroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study. Blood samples for intrinsic and extrinsic TEM (INTEM and EXTEM, respectively) were collected at presentation and every 12 to 24\u2009hours for 48\u2009hours. Coagulation phenotype (hypo-, normo-, or hypercoagulable) was defined based on TEM area under the 1st derivative curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Case fatality rate was 31%. Median TEM variables associated with death (P\u2009&amp;lt;\u2009.05 for all) included longer INTEM clotting time, lower AUC at presentation and at 12 to 24\u2009hours postpresentation (PP), lower INTEM alpha angle, maximum clot firmness, and maximum lysis (ML) at 12 to 24\u2009hours PP, and lower EXTEM ML at 12 to 24\u2009hours PP. Most dogs were normo-coagulable on presentation (66% and 63% on EXTEM and INTEM, respectively), but hypo-coagulable 12 to 24 PP (63% for both EXTEM and INTEM). A hypo-coagulable INTEM phenotype was more frequent at presentation and 12 to 24 PP among nonsurvivors compared to survivors (55% vs 15% and 100% vs 50%, P\u2009=\u2009.045 and .026, respectively). AKI was more frequent (P\u2009=\u2009.015) in dogs with hypo-coagulable INTEM tracings at 12 to 24\u2009hours. Disseminated intravascular coagulation was more frequent (P\u2009&amp;lt;\u2009.05) in dogs with a hypo-coagulable INTEM phenotype and in nonsurvivors at all timepoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Hypocoagulability, based on INTEM AUC, is predictive of worse prognosis and occurrence of secondary complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17041","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:51:10Z","timestamp":1714438270000},"page":"1483-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thromboelastometry for assessment of hemostasis and disease severity in 42 dogs with naturally-occurring heatstroke"],"prefix":"10.1093","volume":"38","author":[{"given":"Michal","family":"Yanai","sequence":"first","affiliation":[{"name":"The Koret School of Veterinary Medicine, The Robert H. 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