{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:51:15Z","timestamp":1784598675267,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":643,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stiftung f\u00fcr Kleintiere der Vetsuisse-Fakult\u00e4t Universit\u00e4t Z\u00fcrich"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Corticosteroids are among the most commonly used drugs in cats and are increasingly discussed as a treatment for feline pancreatitis. However, its effects on serum lipase in healthy cats remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effects of prednisolone on serum lipase activity and pancreatic lipase immunoreactivity (PLI) in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Seven clinically healthy colony cats, aged 4 to 7\u2009years, with unremarkable CBC\/biochemistry panel were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study: Prednisolone (1.1-1.5\u2009mg\/kg, median 1.28\u2009mg\/kg PO) was given daily for 7 consecutive days. Lipase activity (LIPC Roche; RI, 8-26\u2009U\/L) and PLI (Spec fPL; RI, 0-3.5\u2009\u03bcg\/L) were determined at day 1 before first treatment and at days 2, 3, 8, 10, and 14. Cats were examined daily. An a priori power analysis indicated that 6 cats were needed to find a biological relevant effect at 1-\u03b2\u2009=\u20090.8. Statistical analyses comprised the Friedman test, random intercept regression, and repeated-measures linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median (range) day 1 lipase activities and PLI were 22\u2009U\/L (14-52\u2009U\/L) and 3.2\u2009\u03bcg\/L (2.3-15.7\u2009\u03bcg\/L). One cat with abnormally high lipase activity (52\u2009U\/L) and PLI (15.7\u2009\u03bcg\/L) at day 1 continued having elevated lipase activities and PLI throughout the study. Lipase activities and PLI concentrations did not differ significantly among time points regardless of whether the cat with elevated values was included or not. All cats remained healthy throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Administration of prednisolone in anti-inflammatory doses does not significantly increase serum lipase activity and PLI concentration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17042","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T21:04:48Z","timestamp":1710450288000},"page":"1370-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of prednisolone on 1,2-O-dilauryl-rac-glycero glutaric acid-(60-methylresorufin) ester-lipase activity and pancreatic lipase immunoreactivity in healthy cats"],"prefix":"10.1093","volume":"38","author":[{"given":"Militsa","family":"Pacheva","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-0335","authenticated-orcid":false,"given":"Daniel","family":"Brugger","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition and Dietetics, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Riond","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Clinical Laboratory, Department for Clinical Diagnostics and Services, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dennler","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Clinic of Diagnostic Imaging, Department of Clinical Services, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3484","authenticated-orcid":false,"given":"Peter Hendrik","family":"Kook","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"2026020305113232600_jvim17042-bib-0001","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1354\/vp.44-1-39","article-title":"Prevalence and histopathologic characteristics of pancreatitis in cats","volume":"44","author":"de Cock","year":"2007","journal-title":"Vet Pathol"},{"key":"2026020305113232600_jvim17042-bib-0002","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/jvim.13924","article-title":"Comparison of serum spec fPL(\u2122) and 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