{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:22:49Z","timestamp":1777605769210,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":643,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Traditional dosing of chemotherapy drugs based on body surface area may overdose small dogs, leading to an increased frequency of adverse events (AEs).<\/jats:p>\n <\/jats:sec>\n \n Hypothesis\/Objectives<\/jats:title>\n Evaluate the frequency of hematologic and gastrointestinal AEs in dogs with newly diagnosed lymphoma treated with vincristine weighing \u226415\u2009kg in comparison to dogs weighing &gt;15\u2009kg. We hypothesized that dogs weighing \u226415\u2009kg would experience a higher frequency of AEs.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n One hundred and thirty-eight dogs with newly diagnosed lymphoma were treated with vincristine.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A multicenter retrospective study reviewing hematologic data and medical record information. Complete blood counts were performed no more than 24\u2009hours before vincristine administration and then between 4 and 8\u2009days post-administration. Data were evaluated using logistic regression or ordinal logistic regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Thirty-eight dogs weighing \u226415\u2009kg and 100 dogs weighing &gt;15\u2009kg were included. The median vincristine dose for both groups was 0.6\u2009mg\/m2. Seventeen (12.3%) instances of neutropenia occurred with no significant difference in overall frequency or grade between groups. Thirty initially asymptomatic substage A dogs (29.4%) experienced gastrointestinal AEs. Because of the widespread use of gastrointestinal supportive care medications, statistical comparison between groups could not be performed. Seven instances of hospitalization occurred (5.0%) and the risk of hospitalization did not differ significantly between groups (P\u2009=\u2009.37).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n Vincristine dosed at \u22640.6\u2009mg\/m2 does not increase the risk of hematologic AEs in dogs weighing \u226415\u2009kg.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.17063","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T10:05:40Z","timestamp":1712052340000},"page":"1686-1692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vincristine-induced adverse events related to body weight in dogs treated for lymphoma"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-6708","authenticated-orcid":false,"given":"Keira E.","family":"Sztukowski","sequence":"first","affiliation":[{"name":"The Ohio State University College of Veterinary Medicine Department of Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Yaufman","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Veterinary Medicine Department of Clinical Sciences, , Columbus, Ohio,","place":["USA"]},{"name":"Virginia-Maryland College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Roanoke, Virginia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Cook","sequence":"additional","affiliation":[{"name":"Nashville Veterinary Specialists , Nashville, Tennessee,","place":["USA"]},{"name":"Metropolitan Veterinary Hospital , Highland Heights, Ohio,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turi K.","family":"Aarnes","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Veterinary Medicine Department of Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0966-4439","authenticated-orcid":false,"given":"Brian D.","family":"Husbands","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Veterinary Medicine Department of Clinical Sciences, , Columbus, Ohio,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"2026020305115684500_jvim17063-bib-0001","first-page":"182","article-title":"Small Animal Clinical Oncology","author":"Gustafson","year":"2019"},{"issue":"3","key":"2026020305115684500_jvim17063-bib-0002","article-title":"Clinical applications of vinca alkaloids","volume":"179","author":"Rosenthal","year":"1981","journal-title":"J Am Vet Med 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