{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:46:49Z","timestamp":1778629609652,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":643,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment options available for meningoencephalitis of unknown origin (MUO) in dogs are suboptimal, and currently, no single treatment protocol appears to be superior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Compare neurological deterioration rates at 7\u2009days between dogs with MUO treated with corticosteroids alone or combined with cytosine arabinoside (CA) continuous rate infusion (CRI) and compare clinical deterioration and survival at 30 and 100\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-nine dogs with magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) features or both compatible with MUO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Parallel, blinded, randomized controlled trial. Simple randomization into 2 treatment groups: 4\u2009mg\/kg\/day prednisolone (or dexamethasone equivalent) for 2\u2009days or 200\u2009mg\/m2 CA CRI over 8\u2009hours plus 2\u2009mg\/kg\/day prednisolone. Blinding of the treatment protocol was carried out using reversible redaction of clinical records, and treatment failure was defined as deterioration of neurological assessment or death. Using intention-to-treat analysis, proportions failing treatment at 7, 30, and 100\u2009days were compared using Fisher's exact test. All-cause mortality at 100\u2009days was compared using Kaplan-Meier survival curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-five dogs were allocated to corticosteroid only, and 34 dogs were allocated to combined CA CRI and corticosteroid. Proportions failing treatment at 7, 30, and 100\u2009days were 7\/35 (20%), 9\/35 (26%), and 15\/35 (43%) in the corticosteroid-only group and 8\/34 (24%), 11\/34 (32%), and 23\/34 (68%) in the corticosteroid and CA CRI group. All-cause mortality at 100\u2009days was not significantly different between groups (P\u2009=\u2009.62). Clinically relevant treatment-related adverse effects were not observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>We found\u00a0no difference in outcome between corticosteroid monotherapy and combined cytarabine CRI and corticosteroid therapy at 7, 30, and 100\u2009days after diagnosis in dogs with MUO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17088","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T09:08:37Z","timestamp":1714727317000},"page":"1618-1625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Corticosteroid monotherapy versus combined cytarabine continuous rate infusion and corticosteroid therapy in dogs with meningoencephalitis of unknown origin: A blinded, randomized, controlled trial"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1745-284X","authenticated-orcid":false,"given":"Bethan S.","family":"Jones","sequence":"first","affiliation":[{"name":"Langford Vets Small Animal Hospital , Bristol,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois Xavier","family":"Liebel","sequence":"additional","affiliation":[{"name":"Langford Vets Small Animal Hospital , Bristol,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Fadda","sequence":"additional","affiliation":[{"name":"Langford Vets Small Animal Hospital , Bristol,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Martin","sequence":"additional","affiliation":[{"name":"Langford Vets Small Animal Hospital , Bristol,","place":["United 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