{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:42:22Z","timestamp":1788781342940,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":582,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Linnaeus Veterinary Limited supported the costs of the Open Access Publication Charges"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurocandidiasis is systemic candidiasis with central nervous system involvement. This case report describes the clinical presentation, diagnostic test results, and histopathology of a dog with neurocandidiasis. A 3-year-old German shepherd dog was presented for a 3-day history of abnormal mentation, neck pain, and ataxia. Magnetic resonance imaging (MRI) scan of the brain revealed multifocal, small, round, intra-axial lesions within the forebrain. Examination of the cerebrospinal fluid revealed severe neutrophilic inflammation. Extensive testing for infectious diseases was negative. The dog was administered immunosuppressive doses of corticosteroids. The dog's clinical signs improved transiently but got worse 12\u2009days after starting the treatment. Repeat MRI scan revealed multiple, intra-axial, target-like nodular lesions scattered throughout the brain parenchyma. In the temporal muscles, nodules were seen. Cytology of the fine needle aspirates of the nodules in the temporal muscles revealed a neutrophilic inflammation with hyalohyphomycosis. Postmortem examination was compatible with a severe systemic fungal infection. Candida albicans was isolated from the brain, kidney, and heart.<\/jats:p>","DOI":"10.1111\/jvim.17093","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:40:00Z","timestamp":1716252000000},"page":"2362-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological and diagnostic imaging findings in a dog with neurocandidiasis"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8463-3063","authenticated-orcid":false,"given":"Emilie","family":"Royaux","sequence":"first","affiliation":[{"name":"Davies Veterinary Specialists part of Linnaeus Veterinary Limited , Hitchin,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Corbetta","sequence":"additional","affiliation":[{"name":"The Queen's Veterinary Hospital, University of Cambridge , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Czerwi\u00f1ska","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists part of Linnaeus Veterinary Limited , Hitchin,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Gosling","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Group (VPG) , Hitchin,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Aude","family":"Genain","sequence":"additional","affiliation":[{"name":"Cambridge Veterinary School, Veterinary Medicine , Cambridge,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"issue":"4","key":"2026020304092893800_jvim17093-bib-0001","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/vr.142.16.434","article-title":"Acute disseminated candidiasis in a puppy associated with parvoviral infection","volume":"142","author":"Rodr\u00edguez","year":"1998","journal-title":"Vet Rec"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0002","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2460\/javma.2003.223.821","article-title":"Systemic candidiasis in a dog","volume":"223","author":"Heseltine","year":"2003","journal-title":"J Am Vet Med Assoc"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0003","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/104063870501700312","article-title":"Systemic candidiasis in an apparently immunocompetent dog","volume":"17","author":"Brown","year":"2005","journal-title":"J Vet Diagn Invest"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0004","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1292\/jvms.68.1117","article-title":"Systemic candidiasis in a dog, developing spondylitis","volume":"68","author":"Kuwamura","year":"2006","journal-title":"J Vet Med Sci"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1292\/jvms.71.229","article-title":"Systemic candidiasis and mesenteric mast cell tumor with multiple metastases in a dog","volume":"71","author":"Matsuda","year":"2009","journal-title":"J Vet Med Sci"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0006","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1476-4431.2009.00405.x","article-title":"Disseminated candidiasis secondary to fungal and bacterial peritonitis in a young dog","volume":"19","author":"Rogers","year":"2009","journal-title":"J Vet Emerg Crit Care"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0007","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1476-4431.2009.00481.x","article-title":"Candida albicans peritonitis in a dog","volume":"20","author":"Ong","year":"2010","journal-title":"J Vet Emerg Crit Care"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0008","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s11046-016-0092-6","article-title":"Disseminated candidiasis in a young, previously healthy, dog and review of literature","volume":"182","author":"Willems","year":"2017","journal-title":"Mycopathologia"},{"key":"2026020304092893800_jvim17093-bib-0009","first-page":"6","article-title":"Cerebral Candida albicans infection in two dogs","volume":"46","author":"de Souto","year":"2018","journal-title":"Acta Sci Vet"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archinte.1966.03870100055011","article-title":"Candida meningitis","volume":"117","author":"DeVita","year":"1966","journal-title":"Arch Intern Med"},{"issue":"4","key":"2026020304092893800_jvim17093-bib-0011","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00005792-197611000-00004","article-title":"Candida meningitis. 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