{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:04:08Z","timestamp":1787504648320,"version":"build-2736575974"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":582,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The information relating to the outcome specifically for juvenile dogs with meningoencephalitis of unknown etiology (MUE) is lacking.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To describe the clinical presentation, diagnostic findings, treatment, and outcome in a cohort of dogs with MUE &lt;52\u2009weeks old.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Thirty-four client-owned dogs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Multicenter retrospective case series. Records from 5 referral centers were searched. Data was extracted from the medical records and referring veterinarians were contacted for survival data if this was not available from the record.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The mean age was 31\u2009weeks; the youngest dog was 11\u2009weeks and 3 dogs were &lt;16\u2009weeks old. Altered mentation (71%), ataxia (44%), seizures (29%), and circling (26%) were the most common presenting complaints. Neuroanatomical localization was to the forebrain (38%), multifocal (35%), brainstem (18%), and cerebellum (12%). Corticosteroid monotherapy (n\u2009=\u200915) and corticosteroid plus cytosine arabinoside (n\u2009=\u200915) were used in equal proportions. Outcome data was available for 26 dogs, 8 (31%) were alive at the time of data collection with a follow-up range of 135 to 2944\u2009days. Death or euthanasia was related to MUE in 17\/18 dogs that died during the study period. Kaplan-Meier survival analysis demonstrated a median survival time for all-cause death of 84\u2009days.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The prognosis for MUE in this subset of dogs was considered poor.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.17126","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:45:38Z","timestamp":1719452738000},"page":"2214-2220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical features, treatment, and outcome of juvenile dogs with meningoencephalitis of unknown etiology"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-3635","authenticated-orcid":false,"given":"Jack","family":"Galer","sequence":"first","affiliation":[{"name":"Davies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion , Hertfordshire,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Forward","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion , Hertfordshire,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hughes","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists, Part of Linnaeus Veterinary Ltd, Higham Gobion , Hertfordshire,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-5873","authenticated-orcid":false,"given":"Abbe Harper","family":"Crawford","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, Clinical Services Division, Queen Mother Hospital for Animals , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Behr","sequence":"additional","affiliation":[{"name":"Willows Referral Services, Neurology, Highlands Road Shirley , Solihull,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giunio Bruto","family":"Cherubini","sequence":"additional","affiliation":[{"name":"University of Pisa Veterinary Teaching Hospital, Mario Modenato, Department of Veterinary Sciences, , Pisa,","place":["Italy"]},{"name":"Dick White Referrals Ltd, Six Mile Bottom , Cambridgeshire,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ine","family":"Cornelis","sequence":"additional","affiliation":[{"name":"Ghent University Department of Small Animal Medicine and Clinical Biology, , 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