{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:13:58Z","timestamp":1770156838219,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":582,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Methemoglobinemia secondary to administration of hydroxyurea is only reported in veterinary medicine as a result of accidental ingestion of high doses, and once at therapeutic dose in human medicine. A 2.5-year-old female spayed mixed breed dog was presented for acute signs of neurologic disease and diagnosed with severe erythrocytosis without an identified underlying cause, leading to suspicion of polycythemia vera. The dog was managed with phlebotomies, supportive care, and administration of hydroxyurea. Within 2\u2009h of administration of hydroxyurea (37\u2009mg\/kg) administration, respiratory distress with cyanosis, and methemoglobinemia developed. Signs resolved within 24\u2009h but recurred after a second administration of lower dosage of hydroxyurea (17\u2009mg\/kg) 20\u2009days later. The dog remained asymptomatic except for mild cyanosis but was humanely euthanized for lack of relevant improvement of signs of neurologic disease. This case report documents the repeated occurrence of methemoglobinemia in a dog after administration of hydroxyurea at therapeutic doses.<\/jats:p>","DOI":"10.1111\/jvim.17127","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T07:29:03Z","timestamp":1717226943000},"page":"2353-2357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical methemoglobinemia secondary to administration of hydroxyurea at therapeutic doses in a dog"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2038-7529","authenticated-orcid":false,"given":"Manon","family":"Rigot","sequence":"first","affiliation":[{"name":"Ontario Veterinary College, University of Guelph Department of Clinical Studies, , Guelph, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-0256","authenticated-orcid":false,"given":"Shane W.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, University of Guelph Department of Clinical Studies, , Guelph, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu Ting","family":"Yiew","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, University of Guelph Department of Clinical Studies, , Guelph, Ontario,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"issue":"4","key":"2026020304085296700_jvim17127-bib-0001","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1748-5827.2007.00449.x","article-title":"Methaemoglobinaemia caused by hydroxycarbamide (hydroxyurea) ingestion in a 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