{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:29:35Z","timestamp":1791916175896,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":582,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little information exists about vitamin D status in bitches with mammary tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether low plasma vitamin D concentrations are found in bitches with mammary tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eighty-five client-owned bitches with mammary tumors (n\u2009=\u200921 benign, n\u2009=\u200964 malignant) and 39 age-matched healthy bitches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case-control study. Plasma ionized and total calcium, phosphorus, magnesium, urea, creatinine, albumin, total proteins, alanine aminotransferase, alkaline phosphatase, parathyroid hormone (PTH), calcitriol (1,25-dihydroxyvitamin D), and 25-hydroxyvitamin D concentrations were measured in all bitches at the time of clinical diagnosis and before any treatments. Statistical analysis was performed to compare variables among groups (control, benign, and malignant).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences were found when plasma 25-hydroxyvitamin D concentrations in bitches with malignant (148.9 [59.9] ng\/mL) and benign mammary tumors (150.1 [122.3] ng\/mL) were compared with control group (129.9 [54.5] ng\/mL). Parathyroid hormone was significantly higher in bitches with malignant (19.9 [20.5] pg\/mL), and benign mammary tumors (14.6 [14.9] pg\/mL) compared with control group (7.5 [7.5] pg\/mL; P\u2009&amp;lt;\u2009.01). Only the presence of mammary tumors (P\u2009&amp;lt;\u2009.01) and age (P\u2009=\u2009.04; adjusted R2\u2009=\u2009.22) was significant in predicting PTH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bitches with mammary tumors do not have low 25-hydroxyvitamin D concentrations thus vitamin D supplementation is unlikely to be useful for prevention of mammary tumors in bitches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17137","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T03:28:21Z","timestamp":1719804501000},"page":"2257-2264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D status in female dogs with mammary gland tumors"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-8699","authenticated-orcid":false,"given":"Carmen","family":"Pineda","sequence":"first","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]},{"name":"Hospital Cl\u00ednico Veterinario, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Raya","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]},{"name":"Hospital Cl\u00ednico Veterinario, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Morgaz","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]},{"name":"Hospital Cl\u00ednico Veterinario, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"S\u00e1nchez-C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas y Toxicolog\u00eda, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Escol\u00e1stico","family":"Aguilera-Tejero","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]},{"name":"Hospital Cl\u00ednico Veterinario, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]},{"name":"Hospital Cl\u00ednico Veterinario, University of C\u00f3rdoba , C\u00f3rdoba,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"2026020304090892400_jvim17137-bib-0001","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g3656","article-title":"Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United 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