{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:49:57Z","timestamp":1790282997246,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":520,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Institutional Training Grant, National Institutes of Health, Research Training","award":["T32 HL007419"],"award-info":[{"award-number":["T32 HL007419"]}]},{"name":"North Carolina State University Center for Comparative Medicine"},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["CHF 02536-MOU"],"award-info":[{"award-number":["CHF 02536-MOU"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D18CA-821"],"award-info":[{"award-number":["D18CA-821"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["CHF 02536\u2010MOU"],"award-info":[{"award-number":["CHF 02536\u2010MOU"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D18CA\u2010821"],"award-info":[{"award-number":["D18CA\u2010821"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune thrombocytopenia (ITP) is a common cause of severe thrombocytopenia in dogs. The pathogenesis of nonassociative, primary ITP (pITP) appears complex, with ill-defined thrombopoietic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Develop an immunoassay to measure plasma canine thrombopoietin (TPO) concentration and characterize TPO concentrations in dogs with pITP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-one healthy dogs, 8 dogs in an induced ITP model (3 control, 5 ITP), and 58 pITP dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Recombinant canine TPO (rcTPO) was purchased and its identity confirmed by mass spectrometry. Monoclonal antibodies were raised to rcTPO and used to configure a sandwich ELISA using streptavidin-biotin detection. Assay performance, coefficients of variability, and healthy dog plasma TPO reference interval (RI) were determined, followed by assay of ITP samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Assay dynamic range was 15\u2009pg\/mL (lower limit of detection) to 1000\u2009pg\/mL TPO, with limit of quantitation of 62\u2009pg\/mL. Plasma TPO RI was 0 to 158\u2009pg\/mL, with plasma TPO &amp;lt;62\u2009pg\/mL for 35\/41 healthy dogs. All dogs with induced ITP developed marked increases in plasma TPO concentration. Peak values ranged from 515 to &amp;gt;6000\u2009pg\/mL. In contrast, only 2\/58 pITP dogs had TPO values above RI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Plasma TPO concentration is paradoxically low at diagnosis for most dogs with pITP. This finding suggests that ineffective thrombopoiesis contributes to thrombocytopenia in pITP dogs and supports evaluating TPO receptor agonist treatment as used for pITP in humans. The TPO assay provides a new tool to study thrombopoiesis in pITP and other thrombocytopenic syndromes in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17152","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T23:38:22Z","timestamp":1723678702000},"page":"2507-2517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Plasma concentration of thrombopoietin in dogs with immune thrombocytopenia"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-9013","authenticated-orcid":false,"given":"Marjory B.","family":"Brooks","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Brooks","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Catalfamo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New 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