{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:43:44Z","timestamp":1785163424040,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":520,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015900","name":"OVC Pet Trust","doi-asserted-by":"publisher","award":["055180"],"award-info":[{"award-number":["055180"]}],"id":[{"id":"10.13039\/100015900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015900","name":"OVC Pet Trust","doi-asserted-by":"publisher","award":["055180"],"award-info":[{"award-number":["055180"]}],"id":[{"id":"10.13039\/100015900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exogenous iodine interferes with the uptake of radioactive iodine (131I) by the thyroid gland. This has potential implications for the treatment of cats with hyperthyroidism that have recently undergone computed tomography (CT) with IV administration of iodinated contrast medium (ICM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>To determine the time to normalize urinary iodine clearance after administration of ICM. We hypothesized that it would require 4\u2009weeks for urinary iodine concentration (UIC) to decrease to baseline after IV administration of ICM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten healthy adult neutered male cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All cats were sedated and received Iopamidol at a dose of 2\u2009mL\/kg (600\u2009mg\/kg). Urinary iodine and creatinine concentrations were measured before administration of Iopamidol and on days 1, 2, 3, 7, 10 and weeks 2 to 6 after administration. The urinary iodine-to-creatinine ratio (UICR) was calculated. Outcome variables were modeled using a linear mixed-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Urinary iodine concentration increased 37- to 884-fold on Day 1 after ICM injection and returned to baseline during Week 2. Compared with baseline, UIC was significantly increased for Days 1 to 7 (all P\u2009&amp;lt;\u2009.001); UC was significantly lower for Days 1 to 10 (all P\u2009&amp;lt;\u2009.03); and UICR was significantly increased from Days 1 to 10 (all P\u2009&amp;lt;\u2009.001, except Day 10 P\u2009=\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary clearance of iodine after IV administration of ICM requires 10\u2009days to return to baseline in healthy cats. A 2-week interval between the iodinated contrast study and 131I treatment could be appropriate but needs to be confirmed in hyperthyroid cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17172","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T13:44:55Z","timestamp":1725457495000},"page":"2556-2560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urinary iodine clearance after iodinated contrast administration to healthy cats"],"prefix":"10.1093","volume":"38","author":[{"given":"Gabriella","family":"Allegrini","sequence":"first","affiliation":[{"name":"Animal Cancer Centre, Ontario Veterinary College, University of Guelph , Guelph, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-3934","authenticated-orcid":false,"given":"Valerie J.","family":"Poirier","sequence":"additional","affiliation":[{"name":"Animal Cancer Centre, Ontario Veterinary College, University of Guelph , Guelph, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia G.","family":"Pezzali","sequence":"additional","affiliation":[{"name":"Ontario Agricultural College, University of Guelph Department of Animal Biosciences, , Guelph, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hughes H.","family":"Beaufr\u00e8re","sequence":"additional","affiliation":[{"name":"University of California Davis, School of Veterinary Medicine Department of Veterinary Medicine and Epidemiology, , Davis, California,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Shoveller","sequence":"additional","affiliation":[{"name":"Ontario Agricultural College, University of Guelph Department of Animal Biosciences, , Guelph, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Kopke","sequence":"additional","affiliation":[{"name":"Veterinary Nutrition Group , Sydney, New South Wales,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Beeler-Marfisi","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, University of Guelph Department of Pathobiology, , Guelph, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"issue":"5","key":"2026020505521904000_jvim17172-bib-0001","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cvsm.2020.06.004","article-title":"Hyperthyroidism in cats","volume":"50","author":"Peterson","year":"2020","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020505521904000_jvim17172-bib-0002","first-page":"85","article-title":"Diagnosis and management of feline hyperthyroidism: current perspectives","volume":"5","author":"Grauer","year":"2014","journal-title":"Vet Med Res Rep"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0167-5877(88)90041-4","article-title":"Feline hyperthyroidism: a descriptive and case-control study","volume":"6","author":"Scarlett","year":"1988","journal-title":"Prev Vet Med"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0004","doi-asserted-by":"crossref","first-page":"289","DOI":"10.12935\/jvma1951.55.289","article-title":"Prevalence of feline hyperthyroidism in Osaka and the Chugoku region","volume":"55","author":"Miyamoto","year":"2002","journal-title":"J Jap Vet Med Assoc"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0005","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2460\/javma.2004.224.879","article-title":"Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats","volume":"224","author":"Edinboro","year":"2004","journal-title":"J Am Vet Med Assoc"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0006","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jfms.2008.08.001","article-title":"Prevalence of and risk factors for feline hyperthyroidism in Hong Kong","volume":"11","author":"De Wet","year":"2009","journal-title":"J Feline Med Surg"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0007","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2478\/bvip-2014-0040","article-title":"Prevalence of feline hyperthyroidism in mature cats in urban population in Warsaw","volume":"58","author":"G\u00f3jska-Zygner","year":"2014","journal-title":"Bull Vet Inst Pulawy"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0008","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1098612X16643252","article-title":"2016 AAFP guidelines for the management of feline hyperthyroidism","volume":"18","author":"Carney","year":"2016","journal-title":"J Feline Med Surg"},{"key":"2026020505521904000_jvim17172-bib-0009","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.68556","article-title":"Computed Tomography in Veterinary Medicine: Currently Published and Tomorrow's Vision","author":"Keane","year":"2017"},{"key":"2026020505521904000_jvim17172-bib-0010","article-title":"Withrow & MacEwen's Small Animal Clinical Oncology","author":"Withrow","year":"2013","edition":"5th ed."},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0011","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1001\/jamaoto.2013.2552","article-title":"Urinary iodine excretion after contrast computed tomography scan: implications for radioactive iodine use","volume":"139","author":"Nimmons","year":"2013","journal-title":"JAMA Otolaryngol Neck Surg"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0012","first-page":"237","article-title":"Contrast material iodides: potential effects on radioactive iodine thyroid uptake","volume":"33","author":"Laurie","year":"1992","journal-title":"J Nucl Med"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0013","doi-asserted-by":"crossref","first-page":"1751S","DOI":"10.1093\/jn\/132.6.1751S","article-title":"Estimation of iodine status in cats","volume":"132","author":"Ranz","year":"2002","journal-title":"J Nutr"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0014","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1089\/thy.2015.0024","article-title":"Urinary iodine excretion and serum thyroid function in adults after iodinated contrast administration","volume":"25","author":"Lee","year":"2015","journal-title":"Thyroid"},{"key":"2026020505521904000_jvim17172-bib-0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/580569","article-title":"Urinary iodine clearance following iodinated contrast administration: a comparison of euthyroid and postthyroidectomy subjects","volume":"2014","author":"Ho","year":"2014","journal-title":"J Thyroid Res"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0016","first-page":"182","article-title":"The effects of iohexol administration on technetium thyroid scintigraphy in normal cats","volume":"51","author":"Lee","year":"2010","journal-title":"Vet Radiol Ultrasound"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0017","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jfms.2008.02.005","article-title":"Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid cat","volume":"10","author":"Peremans","year":"2008","journal-title":"J Feline Med Surg"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0018","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1373\/49.1.186","article-title":"Fast colorimetric method for measuring urinary iodine","volume":"49","author":"Gnat","year":"2003","journal-title":"Clin Chem"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0019","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2460\/ajvr.70.6.741","article-title":"Urinary iodide concentration in hyperthyroid cats","volume":"70","author":"Wakeling","year":"2009","journal-title":"Am J Vet Res"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0020","first-page":"527","article-title":"The feline iodine requirement is lower than the 2006 NRC recommended allowance","volume":"94","author":"Wedekind","year":"2009","journal-title":"J Anim Physiol Anim Nutr"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0021","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4081\/es.2013.e8","article-title":"Iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism in a community-based cohort","volume":"3","author":"Rhee","year":"2013","journal-title":"Endocrinol Stud"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0022","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1046\/j.1365-2265.2002.01640.x","article-title":"The sodium iodide symporter: its pathophysiological and therapeutic implications: sodium iodide symporter","volume":"57","author":"Spitzweg","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0023","first-page":"832","article-title":"Potential interference of agents on radioiodide thyroid uptake in the euthyroid rat","volume":"44","author":"Yu","year":"2003","journal-title":"J Nuc Med"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0024","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1172\/JCI102310","article-title":"The effect of varying quantities of inorganic iodide (carrier) on the urinary excretion and thyroidal acuumulation of radioiodine in exophthalmic goiter","volume":"29","author":"Childs","year":"1950","journal-title":"J Clin Invest"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0025","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1089\/thy.2012.0099","article-title":"One month is sufficient for urinary iodine to return to its baseline value after the use of water-soluble iodinated contrast agents in post-thyroidectomy patients requiring radioiodine therapy","volume":"22","author":"Padovani","year":"2012","journal-title":"Thyroid"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0026","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2165\/00129784-200303060-00003","article-title":"Contrast nephropathy: an evidence-based approach to prevention","volume":"3","author":"Kandzari","year":"2003","journal-title":"Am J Cardiovasc Drugs"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0027","first-page":"37","article-title":"Contrast media-induced nephrotoxicity\u2014questions and answers","volume":"71","author":"Morcos","year":"1998","journal-title":"Br J Radiol"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0028","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jcrc.2011.05.010","article-title":"Acute kidney injury network definition of contrast-induced nephropathy in the critically ill: incidence and outcome","volume":"26","author":"Lakhal","year":"2011","journal-title":"J Crit Care"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0029","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/01.rli.0000113776.87762.49","article-title":"The cytotoxicity of iodinated radiocontrast agents on renal cells in vitro","volume":"39","author":"Haller","year":"2004","journal-title":"Invest Radiol"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0030","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/vec.12511","article-title":"A retrospective evaluation of contrast-induced kidney injury in dogs (2006-2012): contrast-induced renal injury in dogs","volume":"26","author":"Goic","year":"2016","journal-title":"J Vet Emerg Crit Care"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0031","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/1098612X211038535","article-title":"Does intravenous contrast medium administration result in altered renal biomarkers? A study in clinically stable cats with and without azotemia","volume":"24","author":"Pr\u00fcllage","year":"2022","journal-title":"J Feline Med Surg"},{"issue":"5","key":"2026020505521904000_jvim17172-bib-0032","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/avj.13179","article-title":"Hyperthyroid cats and their kidneys: a literature review","volume":"100","author":"Yu","year":"2022","journal-title":"Aust Vet J"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/38\/5\/2556\/66663668\/jvim17172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/38\/5\/2556\/66663668\/jvim17172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:52:28Z","timestamp":1770288748000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/38\/5\/2556\/8448742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.17172","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2024-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}