{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:09:18Z","timestamp":1786604958801,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":459,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D19-EQ-302"],"award-info":[{"award-number":["D19-EQ-302"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The University of Queensland School of Veterinary Science","award":["VETS5017"],"award-info":[{"award-number":["VETS5017"]}]},{"name":"Open access publishing facilitated by The University of Queensland, as part of the Wiley - The University of Queensland agreement via the Council of Australian University Librarians."},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D19\u2010EQ\u2010302"],"award-info":[{"award-number":["D19\u2010EQ\u2010302"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Characterizing the lipid response to an oral glucose test (OGT) might improve our understanding of Equine Metabolic Syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To describe the effects of an OGT on lipid metabolism and determine the value of measuring triglyceride and nonesterified fatty acid (NEFA) concentrations in hyperinsulinemic (HI) and insulin-resistant (IR) horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty horses including 7 HI-IR horses, 4 HI-non-IR horses, and 9 non-HI-non-IR horses (control).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional design. Horses underwent an OGT, with blood samples collected at 0, 60, 90, and 120\u2009minutes. Insulin, glucose, triglyceride, and NEFA concentrations were measured and compared over time and between groups, with P\u2009&amp;lt;\u2009.05 considered significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all horses, the OGT had a significant effect on triglyceride concentrations (median [interquartile range]: .35 [.30-.50] mmol\/L at 0\u2009minute vs .25 [.21-.37] mmol\/L at 120\u2009minutes, P\u2009=\u2009.005) and on NEFA concentrations (.1 [.1-.2] mEq\/L at 0\u2009minute vs .05 [.05-.1] mEq\/L at 120\u2009minutes, P\u2009=\u2009.0009). However, horses with HI and IR had higher triglyceride areas under the curve (AUC, 79.46\u2009\u00b1\u200946.59 vs 33.32\u2009\u00b1\u20096.75\u2009mmol\/L*min, P\u2009=\u2009.01) as well as NEFA AUC (9.1\u2009\u00b1\u20092.9 vs 6.0\u2009\u00b1\u20096.8\u2009mEq\/L*min, P\u2009=\u2009.03) than control horses. No significant difference was detected between control and HI non-IR horses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Determining triglyceride and NEFA concentrations might help assess tissue insulin resistance during an OGT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17199","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T05:42:18Z","timestamp":1726638138000},"page":"3309-3314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Value of measuring markers of lipid metabolism in horses during an oral glucose test"],"prefix":"10.1093","volume":"38","author":[{"given":"Claire H. K.","family":"Zemek","sequence":"first","affiliation":[{"name":"School of Veterinary Science, The University of Queensland , Gatton, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-5210","authenticated-orcid":false,"given":"Kate L.","family":"Kemp","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland , Gatton, Queensland,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-8431","authenticated-orcid":false,"given":"Fran\u00e7ois-Ren\u00e9","family":"Bertin","sequence":"additional","affiliation":[{"name":"School of Veterinary Science, The University of Queensland , Gatton, Queensland,","place":["Australia"]},{"name":"College of Veterinary Medicine, Purdue University , West-Lafayette, 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