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The diurnal variation of serum phosphorus concentration may affect clinical assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Characterize the diurnal variation of serum phosphorus concentration in cats and determine the associations between changes in serum phosphorus concentration and several metabolites of phosphorus metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six apparently healthy, intact male, specific-pathogen-free cats were housed in a photoperiod, humidity, and temperature-controlled facility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood sampling was performed hourly for 24\u2009hours to obtain the serum concentrations of phosphorus, ionized calcium, parathyroid hormone, and calcidiol. Results were analyzed using linear mixed-effect models to determine the significance of diurnal variation and associations between serum phosphorus concentrations and other metabolites over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Diurnal variation in serum phosphorus concentration was noted with an apex around 11:00 followed by gradually declining concentrations to reach the nadir around 23:00. The serum phosphorus concentration again increased through the early morning on the next day. An approximately 25% difference in serum phosphorus concentration at the apex and the nadir was documented. A non-linear relationship between the serum concentrations of phosphorus and ionized calcium over time was identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Diurnal variations of serum phosphorus concentration and associations between the trending of serum phosphorus and ionized calcium concentrations were evident in a group of clinically healthy adult cats housed in a controlled environment. These findings can help in the interpretation of clinical and research data regarding calcium and phosphorus metabolism and kidney health in cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17202","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T11:55:32Z","timestamp":1727351732000},"page":"3153-3161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diurnal variation of serum phosphorus concentrations in intact male adult domestic cats"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-6586","authenticated-orcid":false,"given":"Chih-Fan","family":"Chiang","sequence":"first","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis , Davis, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Vanderstichel","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Long Island University Department of Clinical Veterinary Sciences, , Brooklyn, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-0128","authenticated-orcid":false,"given":"Jonathan","family":"Stockman","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Long Island University Department of Clinical Veterinary Sciences, , Brooklyn, New York,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-9054","authenticated-orcid":false,"given":"Jennifer A.","family":"Larsen","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California, Davis Department of Molecular Biosciences, , Davis, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-8148","authenticated-orcid":false,"given":"Andrea J.","family":"Fascetti","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California, Davis Department of Molecular Biosciences, , Davis, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"issue":"6","key":"2026020304131629100_jvim17202-bib-0001","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1939-1676.2008.0163.x","article-title":"Survival in cats with naturally occurring chronic kidney disease (2000-2002)","volume":"22","author":"Boyd","year":"2008","journal-title":"J Vet Intern Med"},{"issue":"6","key":"2026020304131629100_jvim17202-bib-0002","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1098612X16631234","article-title":"ISFM Consensus Guidelines on the diagnosis and management of feline chronic kidney disease","volume":"18","author":"Sparkes","year":"2016","journal-title":"J Feline Med Surg"},{"issue":"6","key":"2026020304131629100_jvim17202-bib-0003","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/jvim.16377","article-title":"Renal biomarkers in cats: a review of the current status in chronic kidney disease","volume":"36","author":"Kongtasai","year":"2022","journal-title":"J Vet Intern Med"},{"key":"2026020304131629100_jvim17202-bib-0004","article-title":"Treatment recommendations for CKD in cats; 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