{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:48:52Z","timestamp":1784598532993,"version":"3.55.0"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":459,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral microbleeds (CMBs) are a possible sequela in human brain tumor patients treated with radiation therapy (RT). No such association is reported in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate whether CMBs occur in dogs after radiotherapy, and if there is an association between number and dose, and an increase over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-four client-owned dogs irradiated for primary intracranial neoplasia. \u22652 magnetic resonance imaging (MRI) scans including susceptibility-weighted imaging (SWI) were required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, observational, single-center study. Cerebral microbleeds identified on 3\u2009T SWI were counted within the entire brain, and within low- (&amp;lt;20\u2009Gy), intermediate- (20-30\u2009Gy), and high- (&amp;gt;30\u2009Gy) dose regions. A generalized linear mixed-effects model was used to analyze the relationship between the CMBs count and the predictor variables (irradiation dose, time after treatment).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow-up time was 12.6\u2009months (range, 1.8-37.6\u2009months). Eighty-three MR scans were performed. In 4\/15 dogs (27%, 95% CI, 10%-52%) CMBs were present at baseline. \u22651 CMBs after RT were identified in 21\/34 dogs (62%, 95% CI, 45%-77%). With each month, the number of CMBs increased by 14% (95% CI, 11%-16%; P\u2009&amp;lt;\u2009.001). The odds of developing CMBs in the high-dose region are 4.7 times (95% CI, 3.9-5.6; P\u2009&amp;lt;\u2009.001) greater compared with the low-dose region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>RT is 1 possible cause of CMBs formation in dogs. Cerebral microbleeds are most likely to occur in the peritumoral high-dose volume, to be chronic, and to increase in number over time. Their clinical relevance remains unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17213","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T04:39:39Z","timestamp":1728621579000},"page":"3182-3192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between radiation dose and cerebral microbleed formation in dogs with intracranial tumors"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-2733","authenticated-orcid":false,"given":"Chris","family":"Staudinger","sequence":"first","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Clinic for Diagnostic Imaging, Department of Clinical Diagnostics and Services, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Dennler","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Clinic for Diagnostic Imaging, Department of Clinical Diagnostics and Services, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-4899","authenticated-orcid":false,"given":"Maximilian","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Division of Radiation Oncology, Department for Small Animals, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-7845","authenticated-orcid":false,"given":"Katrin","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Division of Neurology, Department for Small Animals, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-7581","authenticated-orcid":false,"given":"Malwina E.","family":"Kowalska","sequence":"additional","affiliation":[{"name":"Section of Epidemiology, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-9005","authenticated-orcid":false,"given":"Valeria","family":"Meier","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Division of Radiation Oncology, Department for Small Animals, , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-2722","authenticated-orcid":false,"given":"Carla","family":"Rohrer Bley","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, University of Zurich Division of Radiation 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