{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:30:50Z","timestamp":1788622250696,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":398,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1008675"],"award-info":[{"award-number":["2020R1C1C1008675"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1008675"],"award-info":[{"award-number":["2020R1C1C1008675"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nucleated red blood cells (nRBCs) are increased by disease processes and hematopoietic stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the utility of nRBCs as a marker of disease severity and prognosis in dogs with systemic inflammatory response syndrome (SIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-two client-owned dogs met the criteria of SIRS without anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>nRBC-positive (nRBCs: \u22655\/500, n\u2009=\u200932) and nRBC-negative (nRBCs: &amp;lt;5\/500, n\u2009=\u200930) dogs were classified, and clinicopathological data, Acute Patient Physiologic and Laboratory Evaluation (APPLEfast) scores, cytokines, 2- and 4-weeks survival were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median WBC (17.63, interquartile range [IQR]: 11.72-20.24\u2009\u00d7\u2009109\/L), neutrophils (12.28, IQR: 7.17-16.88\u2009\u00d7\u2009109\/L), band neutrophils (1288.5, IQR: 252.5-2575 cells\/\u03bcL), serum IL-6 (731.80, IQR: 299.79-5522.05\u2009pg\/mL), and plasma C-reactive protein (4.10, IQR: 1.00-8.58\u2009mg\/L) were significantly higher in nRBC-positive dogs than negative dogs (11.27, IQR: 7.63-15.13\u2009\u00d7\u2009109\/L; 7.57, IQR: 4.96-11.71\u2009\u00d7\u2009109\/L; 62.5, IQR: 0-350.25 cells\/\u03bcL; 232.30, IQR: 99.33-447.01\u2009pg\/mL; 0.40, IQR: 0.10-3.00\u2009mg\/L, respectively; P\u2009&amp;lt;\u2009.05). The median reticulocyte count (87.95, IQR: 52.45-130.55\u2009\u00d7\u2009103\/\u03bcL) and serum IL-3 (40.94, IQR: 29.85-53.52\u2009ng\/L) were also significantly greater in nRBC-positive dogs than nRBC-negative dogs (46.00, IQR: 26.43-68.15\u2009\u00d7\u2009103\/\u03bcL; 25.24, IQR: 21.65-37.40\u2009ng\/L, respectively; P\u2009&amp;lt;\u2009.01). The presence of circulating nRBCs, but not the reticulocyte count, at admission was predictive of death in dogs with SIRS at 2\u2009weeks (P\u2009=\u2009.01, AUC: 0.729) and 4\u2009weeks (P\u2009=\u2009.002, AUC: 0.731). The overall survival time was shorter in nRBC-positive dogs (95% CI, 47.35-113.90) than nRBC-negative dogs (95% CI, 90.92-135.55; P\u2009=\u2009.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Measuring peripheral nRBCs in dogs with SIRS is rapid and clinically applicable, reflecting disease severity and associated prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17246","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T21:40:18Z","timestamp":1733434818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-5056","authenticated-orcid":false,"given":"ARom","family":"Cho","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-5782","authenticated-orcid":false,"given":"Hyeona","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-6952","authenticated-orcid":false,"given":"Youngju","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-2050","authenticated-orcid":false,"given":"Minjeong","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-4528","authenticated-orcid":false,"given":"Sumin","family":"Cha","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1301-4033","authenticated-orcid":false,"given":"Kyu-Woan","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-6006","authenticated-orcid":false,"given":"Dong-In","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-5717","authenticated-orcid":false,"given":"Jinho","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jeonbuk National University , Iksan 54596,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-6926","authenticated-orcid":false,"given":"DoHyeon","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of 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