{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:08:48Z","timestamp":1788541728199,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":398,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012752","name":"Elanco Animal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012752","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IDEXX Laboratories Inc"},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["BOF.STG.2019.0013.01"],"award-info":[{"award-number":["BOF.STG.2019.0013.01"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012752","name":"Elanco Animal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["BOF.STG.2019.0013.01"],"award-info":[{"award-number":["BOF.STG.2019.0013.01"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Borderline proteinuria is associated with decreased survival in cats with azotemic chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Determine the clinical importance of borderline proteinuria in nonazotemic cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 201 healthy client-owned cats \u22657\u2009years of age; 150 nonproteinuric (urinary protein\u2009:\u2009creatinine ratio [UPC] &amp;lt;0.2) and 51 borderline proteinuric (UPC 0.2-0.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. Cats were thoroughly screened and subsequently examined every 6\u2009months for 2\u2009years. Kaplan-Meier curves were compared between nonproteinuric and borderline proteinuric cats. Univariable and multivariable Cox models were fit to determine the relationship between development of renal disease and potential risk factors such as age, sex, breed, weight, dental disease, blood pressure, serum creatinine concentration (sCrea), serum symmetric dimethylarginine concentration (sSDMA), blood urea nitrogen concentration, urine specific gravity (USG), and UPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significantly more cats with borderline proteinuria at inclusion developed renal disease (International Renal Interest Society [IRIS]\u2009\u2265\u2009stage 2 CKD or renal proteinuria; log-rank P\u2009=\u2009.004) or died (log-rank P\u2009=\u2009.02) within 2\u2009years, compared with nonproteinuric cats. In the multivariate analysis, IRIS stage 1 CKD (persistent USG &amp;lt;1.035 or sSDMA &amp;gt;14\u2009\u03bcg\/dL; hazard ratio [HR], 4.2; 95% confidence interval [CI], 2.0-8.8; P\u2009&amp;lt;\u2009.001), sCrea \u22651.6\u2009mg\/dL (\u2265140\u2009\u03bcmol\/L; HR, 2.6; 95% CI, 1.1-6.4; P\u2009=\u2009.04), borderline proteinuria (HR, 2.5; 95% CI, 1.2-5.2; P\u2009=\u2009.01), and age at inclusion (HR, 1.3; 95% CI, 1.2-1.5; P\u2009&amp;lt;\u2009.001) were significantly associated with diagnosis of renal disease 6\u2009months later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Borderline proteinuria should receive more attention in healthy mature adult and senior cats because it is associated with renal disease and death.<\/jats:p>\n                  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