{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:56:53Z","timestamp":1770148613575,"version":"3.49.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":398,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 9-year-old male castrated golden retriever cross was evaluated for an acute onset of ataxia. A complete blood count revealed marked leukocytosis, anemia, and thrombocytopenia. Leukocytosis was characterized by marked lymphocytosis, monocytosis, neutropenia, and eosinopenia. Flow cytometry identified CD34+ leukocytosis with cells that did not express lineage antigens, suggesting the most likely diagnosis of either acute lymphoid or myeloid leukemia. Leukoreduction via leukapheresis was elected to reduce the disease burden before initiating chemotherapy. Postleukoreduction, the\u00a0dog had a 54% decrease in their white blood cell count. The dog completed multiple weeks of traditional cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-based treatment and had a survival time of 43\u2009days before the owner elected humane euthanasia. To our knowledge, this report represents a case of acute leukemia in a dog treated with leukoreduction before starting chemotherapy.<\/jats:p>","DOI":"10.1111\/jvim.17283","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:14:37Z","timestamp":1734635677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leukoreduction in a dog with acute leukemia"],"prefix":"10.1093","volume":"39","author":[{"given":"Brenna","family":"Hanratty","sequence":"first","affiliation":[{"name":"Friendship Hospital for Animals , Washington, District of Columbia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5846-5583","authenticated-orcid":false,"given":"Anna","family":"Hauck","sequence":"additional","affiliation":[{"name":"Friendship Hospital for Animals , Washington, District of Columbia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Foskett","sequence":"additional","affiliation":[{"name":"Friendship Hospital for Animals , Washington, District of Columbia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D.","family":"Foster","sequence":"additional","affiliation":[{"name":"Friendship Hospital for Animals , Washington, District of Columbia,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"2026020302394707700_jvim17283-bib-0001","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jca.21705","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice\u2014evidence-based approach from the writing Committee of the American Society for Apheresis: the eighth special issue","volume":"34","author":"Padmanabhan","year":"2019","journal-title":"J 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