{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:54:07Z","timestamp":1791395647358,"version":"4.3.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":398,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019245","name":"Companion Animal Health Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019245","name":"Companion Animal Health Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dogs with hepatocutaneous syndrome (HCS) have marked plasma hypoaminoacidemia, but its occurrence in dogs with chronic liver diseases not associated with HCS (non-HCS CLD) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if plasma hypoaminoacidemia occurs in dogs with non-HCS CLD, compare plasma amino acid (PAA) profiles between dogs with non-HCS CLD and HCS, and define a sensitive and specific PAA pattern for diagnosing HCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Data were collected from client-owned dogs, a prospective cohort of 32 with CLD and 1 with HCS, and a retrospective cohort of 7 with HCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. Dogs with chronic serum liver enzyme increases were recruited after hepatic biopsy. Plasma amino acid profiles were measured using high-performance liquid chromatography. Plasma amino acid concentrations were compared between dogs with non-HCS CLD and HCS. Regression analysis was performed to identify a unique PAA pattern for HCS diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve dogs each with vacuolar hepatopathy or chronic hepatitis and 8 dogs with congenital disorders (primary hypoplasia of the portal vein or ductal plate malformations) were enrolled. Compared to non-HCS CLD dogs, HCS dogs had significantly lower plasma concentrations of several amino acids. Regression analysis revealed that glutamine, glycine, citrulline, arginine, and proline concentrations less than 30% of the mean reference value had 100% sensitivity, specificity for diagnosing HCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Generalized plasma hypoaminoacidemia does not accompany non-HCS CLD. Concentrations of 5 specific amino acids less than 30% of the mean reference value can serve as a noninvasive biomarker for diagnosing HCS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.17285","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T05:07:27Z","timestamp":1737349647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma amino acid profiles of dogs with the hepatocutaneous syndrome and dogs with other chronic liver diseases"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-135X","authenticated-orcid":false,"given":"Rommaneeya","family":"Leela-arporn","sequence":"first","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University , North Grafton, Massachusetts,","place":["USA"]},{"name":"Chulabhorn Royal Academy , Bangkok,","place":["Thailand"]},{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University , Fort Collins, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karah Burns","family":"DeMarle","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University , North Grafton, Massachusetts,","place":["USA"]},{"name":"MedVet Norwalk , Norwalk, Connecticut,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-6346","authenticated-orcid":false,"given":"Cailin R.","family":"Heinze","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine at Tufts University , North Grafton, Massachusetts,","place":["USA"]},{"name":"Mark Morris Institute , Topeka, Kansas,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-1826","authenticated-orcid":false,"given":"Cynthia R. 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