{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:05:58Z","timestamp":1770149158479,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":339,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Indices combining diastolic and systolic tissue Doppler variables, the Ee\u2032s\u2032 index (E\/[e\u2032 \u00d7 s\u2032]) and e\u2032a\u2032s\u2032 index (e\u2032\/[a\u2032 \u00d7 s\u2032]), have aided detection of myocardial dysfunction and in prediction of poor outcomes in humans with cardiovascular diseases. Studies of Ee\u2032s\u2032 and e\u2032a\u2032s\u2032 indices in dogs have not been performed.<\/jats:p>\n <\/jats:sec>\n \n Hypothesis\/Objectives<\/jats:title>\n Dogs with pulmonary stenosis (PS) have elevated right ventricular (RV) Ee\u2032s\u2032 and e\u2032a\u2032s\u2032 indices compared to healthy dogs, which will decrease after pulmonary balloon valvuloplasty (BV) or stent implantation.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Thirty client-owned dogs (15 healthy, 15 with PS).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Cross-sectional study. All dogs had echocardiography performed, including the measurement of RV diastolic and systolic variables and calculation of the Ee\u2032s\u2032 and e\u2032a\u2032s\u2032 indices. Dogs with PS had echocardiography performed prior to and after interventional procedures.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The Ee\u2032s\u2032 index was lower (p\u2009=\u2009&lt;\u20090.001) in healthy dogs (median 0.43, range 0.23\u20130.74) compared to dogs with PS pre-operatively (1.49, 0.28\u20133.79). The e\u2032a\u2032s\u2032 index was lower (p\u2009=\u20090.039) in healthy dogs (mean 8.03\u2009\u00b1\u20093.28) compared to dogs with PS pre-operatively (11.39\u2009\u00b1\u20094.03). Compared to pre-operative values, the Ee\u2032s\u2032 index (1.01, 0.36\u20131.62) and e\u2032a\u2032s\u2032 index (8.35\u2009\u00b1\u20093.29) decreased (p\u2009=\u20090.018, p\u2009=\u20090.001, respectively) after pulmonary intervention in dogs with PS.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n Dogs with PS have RV myocardial dysfunction that can be measured with Ee\u2032s\u2032 and e\u2032a\u2032s\u2032 indices, and these values can be used to monitor response to pulmonary intervention over time. These findings suggest that calculation of Ee\u2032s\u2032 and e\u2032a\u2032s\u2032 indices might have clinical importance in long-term management of dogs with PS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.70022","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T03:44:41Z","timestamp":1740195881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of Indices Combining Diastolic and Systolic Tissue Doppler Variables to Evaluate Right Ventricular Function in Dogs With Pulmonary Stenosis"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-4789","authenticated-orcid":false,"given":"Randolph L.","family":"Winter","sequence":"first","affiliation":[{"name":"Auburn University College of Veterinary Medicine , Auburn, Alabama,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara L.","family":"Maneval","sequence":"additional","affiliation":[{"name":"Auburn University College of Veterinary Medicine , Auburn, Alabama,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Serrano","family":"Ferrel","sequence":"additional","affiliation":[{"name":"Auburn University College of Veterinary Medicine , Auburn, Alabama,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"2026020302485864300_jvim70022-bib-0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230160","article-title":"Epidemiological Study of Congenital Heart Diseases in Dogs: Prevalence, Popularity, and Volatility Throughout Twenty Years of Clinical Practice","volume":"15","author":"Brambilla","year":"2020","journal-title":"PLoS 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