{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:30:31Z","timestamp":1785324631021,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":339,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Milner Comparative Oncology Lab"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral primitive neuroectodermal tumor (pPNET) is a very rare, highly malignant tumor encountered in young dogs, with only four necropsy cases in the veterinary literature. A 1.5-year-old male intact French Bulldog presented for evaluation of progressive left forelimb lameness and ipsilateral Horner's syndrome. Whole body computed tomography identified a 12\u2009cm mediastinal mass with extension into the vertebral canal and multifocal metastatic lesions. Histological and immunohistochemical results were consistent with a pPNET. Chemotherapy, radiation therapy, immunotherapy, and targeted therapy were administered. Precision-based tumor testing, including DNA sequencing and chemosensitivity assays, were performed to guide systemic treatment recommendations. A partial remission was observed 3.5\u2009months from presentation based on imaging and improved clinical status. After 7\u2009months of treatment, diffuse metastatic disease, including intracranial spread, was observed and the dog was euthanized.<\/jats:p>","DOI":"10.1111\/jvim.70050","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T07:08:47Z","timestamp":1742195327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multimodal Treatment of a Peripheral Primitive Neuroectodermal Tumor Originating From the Thoracic Cavity in a Dog"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0021-3328","authenticated-orcid":false,"given":"Leah H.","family":"Ackerman","sequence":"first","affiliation":[{"name":"University of Florida College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Gainesville, 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Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Nance","sequence":"additional","affiliation":[{"name":"University of Florida College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash","family":"Sahay","sequence":"additional","affiliation":[{"name":"University of Florida College of Veterinary Medicine Department of Infectious Diseases & Immunology, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela P.","family":"Hery","sequence":"additional","affiliation":[{"name":"University of Florida College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Chan","sequence":"additional","affiliation":[{"name":"University of Florida College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E.","family":"Salute","sequence":"additional","affiliation":[{"name":"University of Florida College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Benslimane","sequence":"additional","affiliation":[{"name":"The Herbert Wertheim University of Florida Scripps Institute Department of Molecular Medicine, , Jupiter, Florida,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virneliz Fernandez","family":"Vega","sequence":"additional","affiliation":[{"name":"The Herbert Wertheim University of Florida Scripps Institute Department of Molecular 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