{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:31:32Z","timestamp":1782837092984,"version":"3.54.5"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":339,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"European College of Veterinary Internal Medicine - Companion Animals (ECVIM-CA) Clinical Studies Fund Purina Institute Resident Research Award"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal secondary hyperparathyroidism (RHPT) is an inevitable consequence of chronic kidney disease (CKD). Paricalcitol might safely attenuate RHPT and proteinuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objective<\/jats:title>\n                    <jats:p>Paricalcitol decreases parathyroid hormone (PTH) and proteinuria in dogs with CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirteen dogs with naturally acquired CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Placebo-controlled clinical trial. Dogs were randomly allocated to receive a placebo or paricalcitol (14\u2009ng\/kg\/day) in a crossover design of 2, 12-week arms. Dogs were evaluated every 3\u2009weeks. Associations between treatment, visit, and the outcome variables were assessed using generalized estimating equations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PTH decreased by 22% (95% CI, 7%\u201335%, p\u2009=\u20090.006) in the paricalcitol-treated dogs and increased by 18% (95% CI, 2%\u201337%, p\u2009=\u20090.022) in the placebo-treated dogs with each visit. FGF-23 at 12\u2009weeks increased compared with baseline in the paricalcitol-treated (mean 6941\u2009pg\/mL, 95% CI, 1781\u201320\u2009057 vs. 489\u2009pg\/mL, 95% CI, 188\u20131272, p\u2009&amp;lt;\u20090.001, respectively), but not in the placebo-treated dogs (696\u2009pg\/mL, 95% CI, 316\u20131531 vs. 955\u2009pg\/mL, 95% CI, 308\u20132963, p\u2009=\u20090.529). Urine protein-to-creatinine ratio at 12\u2009weeks increased compared with baseline in the placebo-treated (0.8, 95% CI, 0.3\u20131.3 vs. 0.5, 95% CI, 0.2\u20130.9, p\u2009=\u20090.04, respectively), but not in the paricalcitol-treated dogs (0.6, 95% CI, 0.3\u20130.9 vs. 1.0, 95% CI, 0.1\u20131.8, p\u2009=\u20090.35). Ionized calcium was unchanged between baseline and 12\u2009weeks in the paricalcitol- and placebo-treated groups (1.3\u2009mmol\/L, 95% CI, 1.29\u20131.35 and 1.34, 95% CI, 1.27\u20131.40 vs. 1.30, 95% CI, 1.25\u20131.35, p\u2009=\u20090.12 and 1.28, 95% CI, 1.24\u20131.32, p\u2009=\u20090.034, respectively). However, 7\/13 dogs developed mild hypercalcemia. Adverse effects were not reported by the owners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Paricalcitol attenuated RHPT and stabilized renal proteinuria in dogs with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70063","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T06:41:34Z","timestamp":1742452894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Paricalcitol on Renal Secondary Hyperparathyroidism and Proteinuria in Dogs With Chronic Kidney Disease"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-9484","authenticated-orcid":false,"given":"Hilla","family":"Chen","sequence":"first","affiliation":[{"name":"Koret School of Veterinary Medicine, The Hebrew University of Jerusalem Department of Small Animal Internal Medicine, , Rehovot,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-3159","authenticated-orcid":false,"given":"Gilad","family":"Segev","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine, The Hebrew University of Jerusalem Department of Small Animal Internal Medicine, , Rehovot,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6193-5817","authenticated-orcid":false,"given":"Michal","family":"Mazaki-Tovi","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine, The Hebrew University of Jerusalem Department of Small Animal Internal Medicine, , Rehovot,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"2026020302494408300_jvim70063-bib-0001","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cvsm.2010.09.004","article-title":"Chronic Kidney Disease in Small Animals","volume":"41","author":"Polzin","year":"2011","journal-title":"Veterinary Clinics of North America: Small Animal Practice"},{"key":"2026020302494408300_jvim70063-bib-0002","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/vr.103059","article-title":"Incidence of and Mortality From Kidney Disease in Over 600,000 Insured Swedish Dogs","volume":"176","author":"Pelander","year":"2015","journal-title":"Veterinary Record"},{"key":"2026020302494408300_jvim70063-bib-0003","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/jvim.12090","article-title":"Chronic Kidney Disease in Dogs in UK Veterinary Practices: Prevalence, Risk Factors, and Survival","volume":"27","author":"O'Neill","year":"2013","journal-title":"Journal of Veterinary Internal Medicine"},{"key":"2026020302494408300_jvim70063-bib-0004","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1172\/JCI106517","article-title":"On the Pathogenesis of Hyperparathyroidism in Chronic Experimental Renal Insufficiency in the Dog","volume":"50","author":"Slatopolsky","year":"1971","journal-title":"Journal of Clinical Investigation"},{"key":"2026020302494408300_jvim70063-bib-0005","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0195-5616(96)50130-0","article-title":"Benefits of Calcitriol Therapy and Serum Phosphorus Control in Dogs and Cats With Chronic Renal Failure. 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