{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:04:07Z","timestamp":1789639447727,"version":"4.0.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":339,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal lipidosis is a well-documented histologic finding in humans and small animals with renal and metabolic disorders, but it is not well described in equids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the signalment, clinicopathologic indices, and postmortem findings of equids with a histologic diagnosis of both hepatic and renal lipidosis (HL\u2009+\u2009RL) and compare them to cases with hepatic lipidosis only (HL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Equids with necropsy findings of renal or hepatic lipidosis (state diagnostic lab) between 2008 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case\u2013control study. Signalment, history, necropsy diagnosis, and selected biochemical data at admission were extracted from medical records. Each case of HL\u2009+\u2009RL was assigned a matched case from group HL for comparison of clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Renal lipidosis was diagnosed in 0.5% (25\/4680) of equid necropsies. Donkeys (7\/13) and pony\/miniature horses (13\/37) with hepatic lipidosis were more likely to also have renal lipidosis compared to horses (5\/141; p\u2009=\u20090.0006, RR\u2009=\u200915.1and p\u2009&amp;lt;\u20090.0001, RR\u2009=\u20099.9, respectively). No cases of renal lipidosis were identified without concurrent hepatic lipidosis. The predominant presenting complaints involved gastrointestinal (16\/25) and neurologic (12\/25) systems. Compared to group HL, group HL\u2009+\u2009RL had significantly higher admission plasma lactate concentration (+6.2\u2009mmol\/L, 95% CI 0.04\u201313.1, p\u2009=\u20090.04) and GGT activity (+246\u2009U\/L, 95% CI \u2212480.4\u20131870, p\u2009=\u20090.02). No significant differences were detected in creatinine or triglyceride concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Renal lipidosis is an occasional postmortem finding in equids with hepatic lipidosis and is more common in donkeys, ponies, and miniature horses compared to horses. The clinical implications of renal lipidosis remain unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70072","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T06:37:39Z","timestamp":1742452659000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Renal Lipidosis in Horses and Donkeys: 25 Cases (2008\u20132022)"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9159-7289","authenticated-orcid":false,"given":"Kali","family":"Slavik","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies \u2013 New Bolton, , Kennett Square, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bender","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Pathobiology, , Kennett Square, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-3562","authenticated-orcid":false,"given":"Leslie","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Studies, , Medford, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-0067","authenticated-orcid":false,"given":"Rose","family":"Nolen-Walston","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies \u2013 New Bolton, , Kennett Square, Pennsylvania,","place":["USA"]},{"name":"Cummings School of Veterinary Medicine, Tufts University Department of Clinical Studies, , Medford, Massachusetts,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"2026020302495301500_jvim70072-bib-0001","doi-asserted-by":"crossref","first-page":"248","DOI":"10.12968\/ukve.2023.7.6.248","article-title":"Lipid Disorders in Horses and Foals","volume":"7","author":"Bertin","year":"2023","journal-title":"UK-Vet Equine"},{"key":"2026020302495301500_jvim70072-bib-0002","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2746\/042516403775467270","article-title":"Severe Hypertriglyceridaemia in Clinically Ill Horses: Diagnosis, Treatment and Outcome","volume":"35","author":"Dunkel","year":"2003","journal-title":"Equine Veterinary Journal"},{"key":"2026020302495301500_jvim70072-bib-0003","first-page":"59","article-title":"Equine Hyperlipidemias Veterinary Clinics of North America","volume":"27","author":"McKenzie","year":"2011","journal-title":"Equine Practice"},{"key":"2026020302495301500_jvim70072-bib-0004","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/evj.12089","article-title":"Severe Hypertriglyceridaemia in Horses and Ponies With Endocrine Disorders","volume":"46","author":"Dunkel","year":"2014","journal-title":"Equine Veterinary Journal"},{"key":"2026020302495301500_jvim70072-bib-0005","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/nu11040722","article-title":"Lipid Accumulation and Chronic Kidney Disease","volume":"11","author":"Gai","year":"2019","journal-title":"Nutrients"},{"key":"2026020302495301500_jvim70072-bib-0006","volume-title":"Large Animal Internal Medicine","author":"Hepatic","year":"2021","edition":"6th ed."},{"key":"2026020302495301500_jvim70072-bib-0007","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ki.1994.100","article-title":"Tubular Lipidosis: Epiphenomenon or Pathogenetic Lesion in Human Renal Disease?","volume":"45","author":"Ong","year":"1994","journal-title":"Kidney International"},{"key":"2026020302495301500_jvim70072-bib-0008","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41581-023-00741-w","article-title":"Kidney Lipid Dysmetabolism and Lipid Droplet Accumulation in Chronic Kidney Disease","volume":"19","author":"Mitrofanova","year":"2023","journal-title":"Nature Reviews. 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