{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:17:35Z","timestamp":1771579055340,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSERC-04979"],"award-info":[{"award-number":["NSERC-04979"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSERC\u201004979"],"award-info":[{"award-number":["NSERC\u201004979"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>After the identification of five novel feline erythrocyte antigens (FEAs) and evidence establishing FEA 1's immunogenicity, attempts to sensitize a cat to FEA 4 unexpectedly resulted in the production of alloantibodies directed against an unknown antigen, named FEA 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To estimate the prevalence of FEA\u20096 as a presumably new antigen, identify corresponding naturally occurring alloantibodies (NOAb), and investigate the associations between known FEAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Two hundread and seven cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective blood typing for FEAs 1\u20136 was conducted in Type A cats (n\u2009=\u2009193), followed by serial crossmatching in groups of 3\u20137 cats to detect NOAb and identify their target FEA. Agreement between FEA 6 blood typing and other FEAs was assessed. Associations between FEAs were evaluated to identify expression patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 193 Type A cats, 67% were FEA\u20096-positive. Agreement analyses were supportive of FEA\u20096 being distinct from FEAs\u20091\u20135. NOAb were detected in 11 cats (5.7%), none of which were anti-FEA 6. Only FEA\u20091-negative status was significantly associated with the presence of NOAb (OR\u2009=\u20096.6, 95% CI, 1.9\u201323.1; p\u2009&amp;lt;\u20090.001). Significant associations were observed between the expressions of FEAs 1 and 4 (\u03c72\u2009=\u200925.7, p\u2009&amp;lt;\u20090.001), and FEAs 3 and 5 (Fisher's exact test, p\u2009&amp;lt;\u20090.001), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>The immunogenicity and prevalence of the newly discovered FEA\u20096 raise concerns regarding its clinical relevance and role in posttransfusion sensitization. FEA 1\/FEA 4 and FEA 3\/FEA 5 pairs might belong to distinct antigenic systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70094","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:31:23Z","timestamp":1744356683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of a Novel Immunogenic Feline Erythrocyte Antigen (FEA 6) and Expression Patterns Between FEAs"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1761-5490","authenticated-orcid":false,"given":"F\u00e9lix","family":"Bajon","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire V\u00e9t\u00e9rinaire, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, University of Montreal , Saint-Hyacinthe,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-7326","authenticated-orcid":false,"given":"Julie","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, University of Montreal Department of Pathology and Microbiology, , Saint-Hyacinthe,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Claude","family":"Blais","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, University of Montreal Department of Clinical Sciences, , 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