{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:17:49Z","timestamp":1771579069077,"version":"3.50.1"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["FWO SBP 2020 006001"],"award-info":[{"award-number":["FWO SBP 2020 006001"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["FWO SBP 2020 006001"],"award-info":[{"award-number":["FWO SBP 2020 006001"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperthyroidism can mask concurrent chronic kidney disease in cats, and no accurate biomarkers are available to predict which cats will develop renal azotemia after radioiodine (131I) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To evaluate the potential of serum and urinary metabolites and metabolite ratios to predict post-131I renal azotemia in hyperthyroid cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Hyperthyroid cats (n\u2009=\u200931), before and (3\u201312 months) after treatment with 131I at the Faculty of Veterinary Medicine (Ghent University, Belgium).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Optimized and validated feline extraction and analysis protocols were employed for metabolic profiling of urine and serum samples using ultra-high performance liquid chromatography\u2013high-resolution mass spectrometry. A dual strategy of cross-validated univariate and penalized multivariate logistic regression was applied to determine predictivity (i.e., area under the curve [AUC], accuracy, sensitivity, and specificity) of individual biomarkers and panels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All hyperthyroid cats were non-azotemic before 131I administration. After 131I treatment, 7 cats became persistently (\u2265\u20092 timepoints) azotemic while 24 remained non-azotemic. Urinary asymmetric dimethylarginine (ADMA) was identified as a pivotal predictor of post-131I azotemia in both univariate and multivariate modeling. When employed as a standalone biomarker, an AUC of 0.851, accuracy of 0.903, sensitivity of 0.714, and specificity of 0.958 were achieved. While pre-treatment USG was significantly different (P = 0.002) between both groups, it did not show enhanced prediction over ADMA, nor in multivariate modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Urinary ADMA can accurately predict post-131I azotemia in hyperthyroid cats becoming euthyroid after 131I treatment. These findings can aid clinicians in managing owner expectations and modify treatment plans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70096","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T06:31:02Z","timestamp":1745476262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Urine Asymmetric Dimethylarginine Concentration to Predict Azotemia in Hyperthyroid Cats After Radio-Iodine Treatment"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-032X","authenticated-orcid":false,"given":"Ellen","family":"Vanden Broecke","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Small Animal Department, , Merelbeke,","place":["Belgium"]},{"name":"Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University Laboratory of Integrative Metabolomics (LIMET), Department of Translational Physiology, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Stammeleer","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Ghent University Small Animal Department, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-1532","authenticated-orcid":false,"given":"Emmelie","family":"Stock","sequence":"additional","affiliation":[{"name":"Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University Department of Morphology, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"De Paepe","sequence":"additional","affiliation":[{"name":"Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University Laboratory of Integrative Metabolomics (LIMET), Department of Translational Physiology, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-7925","authenticated-orcid":false,"given":"Sylvie","family":"Daminet","sequence":"additional","affiliation":[{"name":"Ghent University Small Animal Department, Faculty of Veterinary Medicine, , Merelbeke,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"issue":"3","key":"2026022003484393000_jvim70096-bib-0001","article-title":"Worldwide Prevalence and Risk Factors for Feline Hyperthyroidism: A Review","volume":"85","author":"McLean","year":"2014","journal-title":"Journal of the South African Veterinary Association"},{"issue":"3","key":"2026022003484393000_jvim70096-bib-0002","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/vr.161.21.711","article-title":"Changes in the Glomerular Filtration Rate of 27 Cats With 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