{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:08:37Z","timestamp":1771830517832,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":298,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic acidosis is a common acid\u2013base disorder in critically ill dogs, with fluid therapy being a key but debated treatment. Sodium bicarbonate's risks have spurred interest in safer alternatives such as sodium lactate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the efficacy of a chloride-free, high strong ion difference solution (H-SID) to Ringer's lactate (RL) for treating metabolic acidosis, hypothesizing the superiority of the H-SID solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty-six dogs with metabolic acidosis from two veterinary hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective randomized multicenter study. Dogs were randomly assigned to receive either RL or H-SID at infusion rates of 4 or 10\u2009mL\/kg\/h for 4\u2009h, based on their volume status. H-SID was compounded with sodium (145\u2009mmol\/L), lactate (145\u2009mmol\/L), potassium (10\u2009mmol\/L), and aspartate (10\u2009mmol\/L) in sterile water for injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The H-SID group showed a significant increase in BE-ecf (mmol\/L) at infusion rates of 4\u2009mL\/kg\/h (p\u2009&amp;lt;\u20090.001) and 10\u2009mL\/kg\/h (p\u2009&amp;lt;\u20090.001) when compared to the RL group. At the lower infusion rate, the median increase was 4.1\u2009mmol\/L (95% CI: 3.37, 6.71), whereas the RL group exhibited a variation of \u22120.1 (95% CI: \u22120.75, 2.2). At the higher infusion rate, the median increase was 11\u2009mmol\/L (95% CI: 8.16, 12.52) compared to the RL group variation of 1.3 (95% CI: 0.01, 2.96).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Our results indicate a significant alkalizing effect of the H-SID solution in dogs with non-lactic metabolic acidosis, demonstrating a superior effect compared to the RL solution without notable adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70099","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T02:31:48Z","timestamp":1744770708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of an Iso-Osmotic Chloride-Free Solution With High Strong Ion Difference vs. Ringer's Lactate on Non-Lactate Metabolic Acidosis in Dogs"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-538X","authenticated-orcid":false,"given":"Roberto","family":"Rabozzi","sequence":"first","affiliation":[{"name":"Policlinico Veterinario Roma Sud, AniCura , Roma,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-5060","authenticated-orcid":false,"given":"Stefano","family":"Oricco","sequence":"additional","affiliation":[{"name":"Centro Veterinario Imperiese , Imperia,","place":["Italy"]},{"name":"University of Parma Department of Veterinary Sciences, , Parma,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"issue":"3","key":"2026022301355978800_jvim70099-bib-0001","article-title":"Severe Metabolic or Mixed Acidemia on Intensive Care Unit Admission: Incidence, Prognosis and Administration of Buffer Therapy. 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