{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:15:30Z","timestamp":1785014130134,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic diarrhea (CD) is common in cats, with unknown etiology in many cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To establish the prevalence of feline coronavirus (FCoV) and other enteropathogens in cats with CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Veterinarians at a feline specialty practice examined 493 cats with CD. The breed of three (0.6%) was unknown; 373 (75.7%) were non-purebred, and 117 (23.7%) purebred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective database review of 586 fecal sample results of an RT-PCR and PCR diarrheal panel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Feline coronavirus was found in 321 (65.1%) of 493 cats with CD. FCoV RNA and Clostridium perfringens toxin DNA were detected in 377 (64.3%) and 319 (54.4%) samples respectively: 206 (35.2%) samples were positive for both pathogens. Feline coronavirus was the sole pathogen detected in 118 (23.9%) cats. Samples from 203 cats under 1\u2009year old were significantly (p\u2009=\u20090.0001) more frequently FCoV positive than samples from older cats (166\/224 [74.1%] samples vs. 211\/362 [58.3%]). FCoV RT-PCR positivity peaked in February (p\u2009=\u20090.016) and March (p\u2009=\u20090.0064). Other detected pathogens included Giardia spp. (8.4%; 49\/586 samples); Tritrichomonas blagburni (8.4%; 46\/586); Cryptosporidium (5.1%; 30\/586); Campylobacter jejuni (3.4%; 17\/497); Campylobacter coli (1.6%; 8\/497); Salmonella spp. (0.8%; 5\/586); panleukopenia virus (0.8%; 5\/586); and Toxoplasma gondii (0.5%; 3\/586). Sixty-nine cats gave 162 samples: 54\/69 (78.3%) cats were FCoV positive, 39\/54 (72.2%) persistently so.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>If FCoV is non-pathogenic, as often assumed, its having the highest rate of positivity in CD cases is difficult to explain. If pathogenic and overlooked, key diagnostic and therapeutic opportunities might be missed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70103","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T14:57:40Z","timestamp":1745679460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Feline Coronavirus Prevalence in 493 Cats With Chronic Diarrhea"],"prefix":"10.1093","volume":"39","author":[{"given":"Gary D.","family":"Norsworthy","sequence":"first","affiliation":[{"name":"Alamo Feline Health Center , San Antonio, Texas,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin N.","family":"Miller","sequence":"additional","affiliation":[{"name":"Well Pets Veterinary Clinic and After-Hours Urgent Care , Irmo, South Carolina,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah 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