{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:19:16Z","timestamp":1771579156943,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":295,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02850-A"],"award-info":[{"award-number":["02850-A"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["02850\u2010A"],"award-info":[{"award-number":["02850\u2010A"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fenofibrate improves gut barrier function and reduces serum lipids in purpose-bred dogs with induced diabetes mellitus (DM), but its effects in dogs with naturally occurring DM are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Determine the effects of fenofibrate on markers of systemic and pancreatic inflammation, markers of gut barrier function, lipoprotein profiles, and glycemic control in dogs with naturally occurring DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixteen client-owned dogs with naturally occurring, uncomplicated DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Longitudinal cohort study. Dogs were treated with fenofibrate (Tricor, 6\u201310\u2009mg\/kg, P.O., once daily) for 21\u2009days. Interstitial glucose, serum cytokines, lipopolysaccharide (LPS), pancreatic lipase, and lipid profiles were compared between baseline and day 21 using paired t-tests and Wilcoxon signed-rank tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fenofibrate had no effect on glycemic control, serum cytokines, or serum pancreatic lipase. Compared to baseline, the concentrations of serum LPS decreased at day 21 by (mean\u2009\u00b1\u2009SD) 15\u2009\u00b1\u200924% (95% CI 2\u201328%, p\u2009=\u20090.03), serum triglycerides decreased by 36\u2009\u00b1\u200939% (95% CI 15\u201356%, p\u2009=\u20090.002), and serum cholesterol decreased by 20\u2009\u00b1\u200914% (95% CI 12\u201328%, p\u2009&amp;lt;\u20090.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Fenofibrate treatment was not associated with a decrease in markers of systemic or pancreatic inflammation. In diabetic dogs, short-term fenofibrate treatment appears to be safe, and the improvement in gut barrier function and lipid profiles might lead to long-term benefits, such as reduction in pancreatitis risk and frequency of signs of gastrointestinal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70125","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T03:46:12Z","timestamp":1747626372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Fenofibrate on Markers of Gut Barrier Function in Dogs With Naturally Occurring Diabetes Mellitus"],"prefix":"10.1093","volume":"39","author":[{"given":"Allison L.","family":"O'Kell","sequence":"first","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-9287","authenticated-orcid":false,"given":"Jocelyn","family":"Mott","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0015-3237","authenticated-orcid":false,"given":"Lauren","family":"Porter","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiquitha D.","family":"Crews","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-2414","authenticated-orcid":false,"given":"Yu-An","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Walzem","sequence":"additional","affiliation":[{"name":"Graduate Faculty of Nutrition, Texas A&M University Department of Poultry Sciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3336-2086","authenticated-orcid":false,"given":"Joerg M.","family":"Steiner","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Texas A&M University Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, , College Station, Texas,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-4135","authenticated-orcid":false,"given":"Chen","family":"Gilor","sequence":"additional","affiliation":[{"name":"University of Florida Department of Small Animal Clinical Sciences, , Gainesville, Florida,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"2026022003504577000_jvim70125-bib-0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2024.106241","article-title":"Exocrine Pancreatic Inflammation in Canine Diabetes Mellitus - An Active Offender?","volume":"308","author":"Johnson-Pitt","year":"2024","journal-title":"Veterinary Journal"},{"issue":"3","key":"2026022003504577000_jvim70125-bib-0002","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cvsm.2023.01.004","article-title":"Etiology and Pathophysiology of Diabetes Mellitus in Dogs","volume":"53","author":"O'Kell","year":"2023","journal-title":"Veterinary Clinics of North America. 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