{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:12Z","timestamp":1787731452273,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":217,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute non-compressive nucleus pulposus extrusion (ANNPE), fibrocartilaginous embolism (FCE), and hydrated nucleus pulposus extrusion (HNPE) all present with acute to peracute onset of myelopathic signs in dogs, for which treatment usually is medical. Conservative management including a period of strict rest usually is recommended because of concern about relapse if immediate exercise is allowed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypotheses<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Forty cases of ANNPE, FCE, or HNPE with follow-up including at minimum a 4-week evaluation after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. The exercise group (n\u2009=\u200922) included all dogs the owners of which were not explicitly instructed to rest their dogs, whereas the rest group (n\u2009=\u200918) included all dogs the owners of which were specifically advised to rest their dogs or to restrict their exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No dogs relapsed or deteriorated between discharge and 4-week re-evaluation. No significant difference was found between the rest and exercise groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Allowing exercise after confirming a diagnosis of ANNPE, FCE, or HNPE did not predispose to relapse of clinical signs in the 4\u2009weeks after discharge in our cohort, but the rest group had a higher proportion of HNPE cases, which means interpretation of our findings in this diagnosis must be made with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70135","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T08:59:02Z","timestamp":1748941142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exercise Restriction Does Not Change Outcome in Dogs After Diagnosis of Acute Non-Compressive Nucleus Pulposus Extrusion, Fibrocartilaginous Embolism, or Hydrated Nucleus Pulposus Extrusion"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4582-6183","authenticated-orcid":false,"given":"Katherine","family":"Phillips","sequence":"first","affiliation":[{"name":"Queen's Veterinary School Hospital, University of Cambridge Department of Clinical Veterinary Medicine, , Cambridge,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Freeman","sequence":"additional","affiliation":[{"name":"Queen's Veterinary School Hospital, University of Cambridge Department of Clinical Veterinary Medicine, , Cambridge,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"4","key":"2026020302505270500_jvim70135-bib-0001","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1748-5827.2003.tb00124.x","article-title":"Fibrocartilaginous Embolism in 75 Dogs: Clinical Findings and Factors Influencing the Recovery Rate","volume":"44","author":"Gandini","year":"2003","journal-title":"Journal of Small Animal Practice"},{"key":"2026020302505270500_jvim70135-bib-0002","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2015.00024","article-title":"A Review of Fibrocartilaginous Embolic Myelopathy and Different Types of Peracute Non-Compressive Intervertebral Disk Extrusions in Dogs and Cats","volume":"2","author":"De Risio","year":"2015","journal-title":"Frontiers in Veterinary Science"},{"issue":"4","key":"2026020302505270500_jvim70135-bib-0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/vru.12289","article-title":"Inter- and Intraobserver Agreement for Diagnosing Presumptive Ischemic Myelopathy and Acute Noncompressive Nucleus Pulposus Extrusion in Dogs Using Magnetic Resonance Imaging","volume":"57","author":"Fenn","year":"2016","journal-title":"Veterinary Radiology & Ultrasound"},{"key":"2026020302505270500_jvim70135-bib-0004","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cvsm.2017.08.004","article-title":"Acute Herniation of Nondegenerate Nucleus Pulposus: Acute Noncompressive Nucleus Pulposus Extrusion and Compressive Hydrated Nucleus Pulposus Extrusion","volume":"48","author":"Decker","year":"2018","journal-title":"Veterinary Clinics of North America. 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