{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:18:28Z","timestamp":1789388308212,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Michigan State University College of Veterinary Medicine Endowed Research Funds"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effects of vitamin D supplementation are unknown in dogs with protein-losing enteropathy (PLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety, efficacy, and clinical benefit of orally administered cholecalciferol in dogs with PLE and decreased serum concentrations of 25OHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-eight dogs with PLE, decreased 25OHD, and serum ionized calcium (iCa)\u2009&amp;gt;\u20091.0\u2009mmol\/L (n\u2009=\u200915 treated with cholecalciferol, n\u2009=\u200913 treated with placebo).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, double-blinded, randomized, controlled trial. Dogs randomized to receive 400\u2009IU\/kg cholecalciferol or placebo PO daily along with standard therapy for 6\u2009weeks. Clinical and biochemical variables were measured at baseline (T0) and monitored at 2 (T1), 4 (T2), and 6 (T3) weeks postmedication initiation. Clinical and biochemical variables were also measured 6\u2009weeks following discontinuation of study medication (T4). Variables were compared in dogs with PLE receiving cholecalciferol versus placebo at T0\u2013T4 using Student's t test or Mann\u2013Whitney U tests and a mixed-effects model. Correlations between 25OHD and clinical and biochemical variables were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs with PLE treated with cholecalciferol had higher 25OHD concentrations at T2 compared to dogs treated with placebo (225\u2009nmol\/L, range 72\u2013434 vs. 80\u2009nmol\/L, range 31\u2013254\u2009nmol\/L; p\u2009=\u20090.004). Clinical and biochemical variables did not otherwise differ between dogs with PLE treated with cholecalciferol versus placebo at T0\u2013T4. Serum albumin correlated with 25OHD at T0\u2013T3(p\u2009&amp;lt;\u20090.005 for all comparisons). Hypervitaminosis D without ionized hypercalcemia occurred in five dogs (18%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While PLE dogs treated with cholecalciferol had higher 25OHD concentrations at study timepoints, a clinical benefit of supplementation was not observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70147","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:10:18Z","timestamp":1749427818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of Hypovitaminosis D With Cholecalciferol in Dogs With Protein-Losing Enteropathies: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-3644","authenticated-orcid":false,"given":"Sara A.","family":"Jablonski","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, Michigan,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Shropshire","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Watson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Pathobiology and Diagnostic Investigation, , East Lansing, Michigan,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison C.","family":"Manchester","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, Colorado,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-2307","authenticated-orcid":false,"given":"Harry","family":"Cridge","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, Michigan,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9988-4365","authenticated-orcid":false,"given":"Elizabeth M.","family":"Lennon","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, School of Veterinary Medicine Department of Small Animal Clinical Science, , Philadelphia, Pennsylvania,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-9530","authenticated-orcid":false,"given":"M. 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