{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:42:30Z","timestamp":1779921750150,"version":"3.53.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebrospinal fluid (CSF) collection is routinely performed in dogs with neurological disorders. Little is known about the rate of major complications associated with CSF collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Determine the number of dogs experiencing a major complication secondary to CSF collection in a single referral hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eleven dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single-center, retrospective description of the number and nature of major complications encountered during or after CSF collection in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 7545 CSF collections performed between 1998 and 2024, 11 dogs (0.15%) experienced a major complication. Eight of these dogs had abnormal mentation on presentation. The most common neuroanatomical localization was multifocal (5\/11). Nine dogs underwent magnetic resonance imaging (MRI) of the head and one dog had radiographs of the cervical vertebral column before CSF collection. The most common MRI findings included effacement of the cerebral sulci (7\/9) and dilatation of the ventricular system (5\/9). Cerebrospinal fluid collection was performed in 11 dogs, of which 3 were unsuccessful. Analysis of CSF aided in the diagnosis of meningoencephalitis of unknown origin (3\/8), cryptococcosis (1\/8), lymphoma (1\/8), and results were normal in one and non-specific in two dogs. Eight dogs were euthanized after failure to recover spontaneous ventilation (6), cardiopulmonary arrest (1) or severe neurological deterioration (1). One dog died during cardiopulmonary resuscitation. Repeat MRI after CSF collection identified caudal transtentorial and foramen magnum herniation in one dog. Two dogs survived to hospital discharge but with permanent neurological deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The frequency of major complications following CSF collection was low, but the associated mortality was high. Abnormal mentation and MRI evidence of cerebral cortical swelling were commonly detected before CSF collection in dogs experiencing complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70165","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T10:54:11Z","timestamp":1750157651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1394-920X","authenticated-orcid":false,"given":"Cecilia-Gabriella","family":"Danciu","sequence":"first","affiliation":[{"name":"Veterinary Clinical Science and Services, Royal Veterinary College, University of London , Hatfield,","place":["UK"]},{"name":"Small Animal Teaching Hospital, University of Liverpool , 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