{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:01:10Z","timestamp":1771999270583,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 12-year-old, male Labrador Retriever was presented because of polyuria, polydipsia, polyphagia, joint pain, and physical features consistent with acromegaly. Circulating insulin-like growth factor-1 (IGF-1) concentration was increased (&amp;gt;\u20091000\u2009ng\/mL; reference interval [RI], 42\u2013449), suggestive of hypersomatotropism. An abnormal low-dose dexamethasone suppression test and increased circulating adrenocorticotropic (ACTH) concentration indicated pituitary-dependent hypercortisolism. Computed tomography identified an enlarged pituitary gland. Treatment with cabergoline initially decreased circulating IGF-1 and ACTH concentrations and urinary cortisol-to-creatinine ratio (UCCR), with a notable reduction in acromegalic physical features. However, 7\u2009months after the start of cabergoline treatment, IGF-1, ACTH, and UCCR had increased again, although pituitary gland size remained stable. Because of worsening joint pain, euthanasia was performed. On necropsy, double immunohistochemistry identified pituitary tumor cells with cytoplasmic co-expression of both growth hormone (GH) and ACTH, consistent with a monomorphic plurihormonal macroadenoma. This case shows that concurrent hypersomatotropism and hypercortisolism can occur in dogs caused by a plurihormonal pituitary adenoma.<\/jats:p>","DOI":"10.1111\/jvim.70177","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T03:34:55Z","timestamp":1750131295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-4748","authenticated-orcid":false,"given":"Elber A.","family":"Soler Arias","sequence":"first","affiliation":[{"name":"Unidad de Endocrinolog\u00eda, Hospital Escuela de Veterinaria, Universidad de Buenos Aires , Ciudad Aut\u00f3noma de Buenos Aires, Buenos Aires,","place":["Argentina"]},{"name":"Servicio de Endocrinolog\u00eda Veterinaria, Endovett , Ciudad Aut\u00f3noma de Buenos Aires, Buenos Aires,","place":["Argentina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7994-6428","authenticated-orcid":false,"given":"Ricardo","family":"Rodas Elvir","sequence":"additional","affiliation":[{"name":"Servicio de Nefrourolog\u00eda, RenalvetCR, Hospital Veterinario Intensivet , San Jos\u00e9,","place":["Costa Rica"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-2975","authenticated-orcid":false,"given":"Adrian F.","family":"Daly","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Li\u00e8ge, University of Li\u00e8ge Department of Endocrinology, , Li\u00e8ge,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-0492","authenticated-orcid":false,"given":"Hans S.","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht 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