{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:25:40Z","timestamp":1791440740376,"version":"4.3.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018835","name":"Albert-Heim-Stiftung","doi-asserted-by":"publisher","award":["143"],"award-info":[{"award-number":["143"]}],"id":[{"id":"10.13039\/100018835","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Open access publishing facilitated by Universitat Zurich, as part of the Wiley - Universitat Zurich agreement via the Consortium Of Swiss Academic Libraries."},{"DOI":"10.13039\/100018835","name":"Albert-Heim-Stiftung","doi-asserted-by":"publisher","award":["143"],"award-info":[{"award-number":["143"]}],"id":[{"id":"10.13039\/100018835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No data after hospitalization for acute pancreatitis (AP) in dogs comparing clinical signs to lipase results exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate disease severity, lipase activity, and pancreatic lipase immunoreactivity (PLI) after hospitalization for suspected AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred and six client-owned dogs with a minimum of one re-check 2\u2009weeks after hospitalization for AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Combined retrospective and prospective study. Clinical signs graded using a clinical disease activity score (CDAS\u2009=\u2009CIBDAI complemented by abdominal pain) were compared to DGGR-lipase activity (LIPC Roche) and PLI (SpecPL) at 2\u2009weeks (t2, n\u2009=\u2009106) after discharge. Additional re-checks were available 6\u2009weeks (t3, n\u2009=\u200956), 12\u2009weeks (t4, n\u2009=\u200924), and 24\u2009weeks (t5, n\u2009=\u200913) after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lipase activity and PLI correlated strongly at all time points (rs 0.863\u20130.937, p\u2009&amp;lt;\u20090.0001). Discordant results in regard to published reference intervals (RI) were rare (2.8% at t2, 1.7% at t3, 4.2% at t4, 0% at t5) and seemed clinically irrelevant. Dogs with still elevated lipase activity and PLI at t2 (24\/106.22.6%) and t3 (21\/56.37.5%) were significantly older compared to dogs with lipase within RI. Weak and moderate correlation between CDAS and lipase activity\/PLI was found only at t2 (rs 0.391, p\u2009=\u20090.0009; rs 0.279, p\u2009=\u20090.004) and t5 (rs 0.603, p\u2009=\u20090.032; rs 0.57 p\u2009=\u20090.045). Most dogs (79.2%) with still elevated lipase at t2 had no or minimal clinical signs (CDAS 0\u20133). The same applied to all later re-checks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Both lipase assays did not differ when compared to clinical status. Most dogs with hyperlipasemia after hospitalization for AP have no or minimal clinical signs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70188","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T09:35:28Z","timestamp":1754040928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Hyperlipasemia and Clinical Signs in 106 Dogs After Hospitalization for Acute Pancreatitis: Results From a Combined Retrospective and Prospective Follow-Up Study"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3484","authenticated-orcid":false,"given":"Peter H.","family":"Kook","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , 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