{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:14:51Z","timestamp":1771578891125,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":234,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 10-year-old mixed-breed dog was presented with progressive neurological deficits suggestive of polyneuropathy. CT and MRI revealed no relevant abnormalities, whereas the CSF analysis showed a marked lymphocytic pleocytosis, immunocytochemically classified as T-cell lymphoma. Chemotherapy ensued with no improvement of clinical signs. Cerebrospinal fluid reanalysis still revealed a mild lymphocytic pleocytosis. MRI of the brain and spinal cord solely showed a reduced ventral subarachnoid and epidural space (Th11-L2) and mild enlargement of the central canal in this area. Postmortem examination revealed thickening of the spinal nerve roots and ganglia. Histologically, a marked intraspinal-subdural and intraneural, as well as intra-ganglionic, infiltration by large lymphocytes in the peripheral nervous system was visible. Immunohistochemically, the infiltrating lymphoblasts were CD3 positive, confirming T-cell origin. Neurolymphomatosis is a rarely described neoplastic disease in dogs. The present case highlights the importance of analysis of CSF in neurologically abnormal dogs.<\/jats:p>","DOI":"10.1111\/jvim.70189","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:28:01Z","timestamp":1753345681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurolymphomatosis of T-Cell Origin in a Dog"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8677-4921","authenticated-orcid":false,"given":"Marie-Kerstin","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"AniCura Potsdam GmbH , Potsdam,","place":["Germany"]},{"name":"IDEXX Vet Med Labor GmbH , Kornwestheim,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Irmscher","sequence":"additional","affiliation":[{"name":"AniCura Potsdam GmbH , Potsdam,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Goldbach","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Dr. Soerensen GmbH , Berlin,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander F. H.","family":"Haake","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tierpathologie, Freie Universit\u00e4t Berlin , Berlin,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Kershaw","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tierpathologie, Freie Universit\u00e4t Berlin , Berlin,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope A.","family":"Baloi","sequence":"additional","affiliation":[{"name":"Vet-CT , Cambridge,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"4","key":"2026022003443777100_jvim70189-bib-0001","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1182\/blood-2009-12-258210","article-title":"Neurolymphomatosis: An International Primary CNS Lymphoma Collaborative Group 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