{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:15:57Z","timestamp":1787318157189,"version":"build-2736575974"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Boehringer Ingelheim Vetmedica GmbH"},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/T008709\/1"],"award-info":[{"award-number":["BB\/T008709\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/T008709\/1"],"award-info":[{"award-number":["BB\/T008709\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multi-steroid profiles are proven to help with the diagnostic approach to adrenal disorders in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Compare liquid chromatography tandem mass spectrometry (LC\u2013MS\/MS) and radioimmunoassay (RIA) measurement of aldosterone in feline blood samples. Evaluate multi-steroid profiles in cats with hyperaldosteronism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client-owned cats with low\/normal aldosterone by RIA (low aldo, n\u2009=\u200915), high aldosterone by RIA (high aldo, n\u2009=\u20096) and overt primary hyperaldosteronism (PHA, n\u2009=\u20096).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Exploratory retrospective case\u2013control study. Feline blood multi-steroid profiles were analyzed with LC\u2013MS\/MS and compared with results from a commercially available RIA in widespread clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aldosterone measurement by LC\u2013MS\/MS and RIA was strongly correlated (r\u2009=\u20090.93, p\u2009&amp;lt;\u20090.001) but showed a bias of 56 (95% CI: 104\u20137) pmol\/L, with RIA giving higher values. Creatinine concentration was not significantly associated with the discrepancy between methods (p\u2009=\u20090.95). Cats with PHA had significantly lower serum concentrations of cortisol and glucocorticoid precursors (17-hydroxyprogesterone, 11-deoxycortisol), testosterone, and significantly higher dihydrotestosterone and 5\u03b1-dihydroprogesterone concentrations than the low aldo group. Pregnenolone concentrations were significantly lower in the PHA group than in the high aldo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Quantification of aldosterone by either LC\u2013MS\/MS or RIA is adequate for PHA diagnosis in the clinical setting, with appropriate method-specific reference intervals. Cats with PHA had different concentrations of some steroids compared with the control groups, but overt steroid excess (other than aldosterone) was not observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70209","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:59:50Z","timestamp":1755226790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Determination of Multi-Steroid Profiles of Cats With Hyperaldosteronism or Other Diseases: A\u00a0Retrospective Study"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1048-6521","authenticated-orcid":false,"given":"Alice H.","family":"Watson","sequence":"first","affiliation":[{"name":"Royal Veterinary College , London,","place":["UK"]},{"name":"Queen Mary, University of London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna 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