{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:00:46Z","timestamp":1792803646088,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Outcome-based cardiac risk stratification schemes are lacking for preclinical myxomatous mitral valve disease (MMVD). The Mitral INsufficiency Echocardiographic (MINE) score was developed as an easy-to-use severity classification of MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The primary aim was to verify the efficacy of the MINE score in stratifying the cardiac risk in preclinical MMVD. Secondary aims were to evaluate a simplification of the original score and propose a definition of \u201cadvanced B2\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Seven hundred forty-nine dogs with preclinical MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, multicenter, cohort study. Clinical usefulness of the MINE score was tested by evaluating its association with median time to cardiac event. The Cox proportional hazards regression was used to evaluate the echocardiographic independent predictors of cardiac endpoint. Long-term outcome was analyzed using Kaplan\u2013Meier curves and log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on multivariate analysis, a simplified version of the MINE score was redefined including only the left atrium-to-aorta ratio, the left ventricular end-diastolic diameter, and the E-wave velocity. Mild cases had longer median time to cardiac event [2604\u2009days, 95% confidence interval (CI) 2344\u20132604\u2009days] in comparison to moderate (1216\u2009days, 95% CI 998\u20131882\u2009days) and severe cases (718\u2009days, 95% CI 599\u2013980\u2009days; p\u2009&amp;lt;\u20090.001). Among stage B2, severe cases had shorter median time to cardiac event (718\u2009days, 95% CI 599\u2013980\u2009days) in comparison to moderate (1141\u2009days, 95% CI 980\u20131725\u2009days) and mild cases (not available; p\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>For this study cohort, the simplified version of the MINE score was clinically effective for risk stratification of preclinical MMVD. Dogs in stage B2 classified as \u201csevere\u201d can be defined \u201cadvanced\u201d B2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.70215","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:14:27Z","timestamp":1756322067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk Stratification Using Mitral INsufficiency Echocardiographic Score 2 in Dogs With Preclinical Mitral Valve Disease"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-6582","authenticated-orcid":false,"given":"Tommaso","family":"Vezzosi","sequence":"first","affiliation":[{"name":"University of Pisa Department of Veterinary Sciences, , Pisa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Grosso","sequence":"additional","affiliation":[{"name":"University of Pisa Department of Veterinary 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Novara,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Marchesotti","sequence":"additional","affiliation":[{"name":"Anicura Istituto Veterinario Novara , Novara,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-9176","authenticated-orcid":false,"given":"Rosalba","family":"Tognetti","sequence":"additional","affiliation":[{"name":"University of Pisa Department of Veterinary Sciences, , Pisa,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-1780","authenticated-orcid":false,"given":"Mark","family":"Rishniw","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Domenech","sequence":"additional","affiliation":[{"name":"Anicura Clinica 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