{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:25:18Z","timestamp":1771579518064,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Helsinki Fund for Veterinary Medicine\/Fund for Research in Canine Health"},{"name":"Open access publishing facilitated by Helsingin yliopisto, as part of the Wiley - FinELib agreement."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cholesterol ester storage disease (CESD) is a rare genetic lysosomal storage disorder resulting from lower lysosomal acid lipase (LAL) activity. LAL is an essential enzyme required in intracellular lipid metabolism, and deficiency results in disability to properly break down and utilize lipids and in the accumulation of especially cholesterol esters in many organs such as the liver, spleen, and bone marrow. This case report describes clinical findings, LAL activity measurement, blood and liver tissue lipidomic changes, as well as pathological findings in two unrelated Field Spaniels with LAL deficiency and CESD.<\/jats:p>","DOI":"10.1111\/jvim.70223","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T05:29:32Z","timestamp":1756272572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol Ester Storage Disease in Two Field Spaniels With Lysosomal Acid Lipase Deficiency"],"prefix":"10.1093","volume":"39","author":[{"given":"Pernilla","family":"Syrj\u00e4","sequence":"first","affiliation":[{"name":"Section for Veterinary Pathology and Parasitology, Faculty of Veterinary Medicine, University of Helsinki Department of Veterinary Biosciences, , Helsinki,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilda M. H.","family":"Ylenius","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Helsinki Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilda","family":"Kr\u00e5kstr\u00f6m","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre, University of Turku , Turku,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex M.","family":"Dickens","sequence":"additional","affiliation":[{"name":"Turku Bioscience Centre, University of Turku , Turku,","place":["Finland"]},{"name":"University of Turku Department of Chemistry, , Turku,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-7559","authenticated-orcid":false,"given":"Elina","family":"Rautala","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Helsinki Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Huupponen","sequence":"additional","affiliation":[{"name":"Section for Veterinary Pathology and Parasitology, Faculty of Veterinary Medicine, University of Helsinki Department of Veterinary Biosciences, , Helsinki,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Carditech , Espoo,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-5799","authenticated-orcid":false,"given":"Sanna J.","family":"Viitanen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Helsinki Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"2026022003572453200_jvim70223-bib-0001","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: Towards a Unified Platform for Metabolomics Data Processing, Analysis and Interpretation","volume":"52","author":"Pa","year":"2024","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"2026022003572453200_jvim70223-bib-0002","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jhep.2013.02.014","article-title":"Cholesteryl Ester Storage Disease: Review of the Findings in 135 Reported Patients With an Underdiagnosed Disease","volume":"58","author":"Bernstein","year":"2013","journal-title":"Journal of Hepatology"},{"issue":"5","key":"2026022003572453200_jvim70223-bib-0003","doi-asserted-by":"crossref","first-page":"429.e1","DOI":"10.1016\/j.medcli.2016.12.044","article-title":"Update on Lysosomal Acid Lipase Deficiency: Diagnosis, Treatment and Patient Management","volume":"148","author":"Camarena","year":"2017","journal-title":"Medicina Cl\u00ednica (Barcelona)"},{"key":"2026022003572453200_jvim70223-bib-0004","first-page":"79","article-title":"Lysosomal Acid Lipase Deficiency - 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