{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:09:30Z","timestamp":1781784570198,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":171,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 5-year-old Basenji Mix achieved extended survival with treatment for disseminated protothecosis. The dog originally presented with iridal hyperemia and ocular ultrasonographic examination revealed a mass effect. Histopathology revealed ocular protothecosis and staging confirmed disseminated protothecosis. Treatment with itraconazole and amphotericin B (AmB) infusions resulted in remission. Four years later, restaging revealed recurrence of infection in colonic biopsy samples. An extended AmB protocol was restarted for a cumulative dose of 84\u2009mg\/kg and the dog received isavuconazole based on susceptibility testing. The dog was euthanized 4\u2009years and 8\u2009months after initial diagnosis due to decline of neurologic status. Necropsy confirmed the presence of disseminated protothecosis in multiple arteries, multiple lymph nodes, the pituitary gland, thyroid glands, kidneys, colon, cecum, right eyelid, right eye, heart, brain, and periosteum of one bone associated with the middle ear. This report documents the extended survival of a dog with widespread disseminated protothecosis after prolonged administration of AmB.<\/jats:p>","DOI":"10.1111\/jvim.70231","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:54:35Z","timestamp":1756284875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extended Survival in a Dog With Disseminated Protothecosis"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4762-0098","authenticated-orcid":false,"given":"Bianca G.","family":"Landfield","sequence":"first","affiliation":[{"name":"Schwarzman Animal Medical Center Department of Internal Medicine, , New York, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-4354","authenticated-orcid":false,"given":"Elizabeth H.","family":"Appleman","sequence":"additional","affiliation":[{"name":"Schwarzman Animal Medical Center Department of Internal Medicine, , New York, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Daverio","sequence":"additional","affiliation":[{"name":"Schwarzman Animal Medical Center Department of Anatomic Pathology, , New York, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-7448","authenticated-orcid":false,"given":"Cassandra","family":"Guarino","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Elizabeth","family":"Moore","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Gioia","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, New York,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"2026022003564629200_jvim70231-bib-0001","first-page":"1126","volume-title":"Greene's Infectious Diseases of the Dog and Cat","author":"Sykes","year":"2023","edition":"5th ed."},{"key":"2026022003564629200_jvim70231-bib-0002","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2878751","article-title":"Cutaneous Disease as Sole Clinical Manifestation of Protothecosis in a Boxer Dog","volume":"2016","author":"Papadogiannakis","year":"2016","journal-title":"Case Reports in Veterinary 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